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LPH-48 is a selective serotonin 5-HT2A receptor agonist and psychedelic hallucinogen which is under development for the treatment of alcoholism.[1][2][3] Its route of administration has not been specified.[1]
| Clinical data | |
|---|---|
| Other names | LPH48 |
| Routes of administration | Unspecified[1] |
| Drug class | Selective serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen[1][2] |
The drug acts as a selective agonist of the serotonin 5-HT2A receptor.[1][2][3] It is said to be an analogue of LPH-5 with similar characteristics but with faster metabolism and a shorter duration of action.[3] LPH-5 is a highly selective serotonin 5-HT2A receptor agonist that is under development for major depressive disorder and has shown antidepressant-like effects in animals.[4][5][6]
LPH-48 is under development by Lophora.[1][2] As of May 2024, it is in preclinical research for alcoholism.[1][2] The chemical structure of LPH-48 does not yet seem to have been disclosed.[1] However, Lophora has patented selective serotonin 5-HT2A receptor agonists for treatment of depression[7] and the company is said to have patent protection for LPH-48.[1] Additionally, the structure of its close analogue LPH-5 is known and this compound is a phenylpiperidine derivative.[4]
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