LPAR4

Lysophosphatidic acid receptor 4 also known as LPA₄ is a protein that in humans is encoded by the LPAR4 gene.^[5][6][7] LPA₄ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[8]

LPAR4
Identifiers
Aliases	LPAR4, GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9, lysophosphatidic acid receptor 4
External IDs	OMIM: 300086; MGI: 1925384; HomoloGene: 3871; GeneCards: LPAR4; OMA:LPAR4 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.1 Start 78,747,709 bp[1] End 78,758,714 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 105,964,231 bp[2] End 105,977,506 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve buccal mucosa cell tibia testicle gonad ventricular zone cartilage tissue ganglionic eminence muscle of thigh Achilles tendon Top expressed in dermis pituitary stalk efferent ductule human fetus primitive streak trigeminal ganglion tongue Gonadal ridge mandibular prominence left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lysophosphatidic acid binding signal transducer activity lipid binding G protein-coupled receptor activity lysophosphatidic acid receptor activity Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane nuclear body intracellular membrane-bounded organelle Biological process signal transduction positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2846 78134 Ensembl ENSG00000147145 ENSMUSG00000049929 UniProt Q99677 Q8BLG2 RefSeq (mRNA) NM_001278000 NM_005296 NM_175271 RefSeq (protein) NP_001264929 NP_005287 NP_780480 Location (UCSC) Chr X: 78.75 – 78.76 Mb Chr X: 105.96 – 105.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Lysophospholipid receptor
• P2Y receptor

References

1. GRCh38: Ensembl release 89: ENSG00000147145 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049929 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR23 G protein-coupled receptor 23".
6. Janssens R, Boeynaems JM, Godart M, Communi D (July 1997). "Cloning of a human heptahelical receptor closely related to the P2Y5 receptor". Biochem. Biophys. Res. Commun. 236 (1): 106–12. doi:10.1006/bbrc.1997.6895. PMID 9223435.
7. O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR (March 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene. 187 (1): 75–81. doi:10.1016/S0378-1119(96)00722-6. PMID 9073069.
8. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

Further reading

• Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim. Biophys. Acta. 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Noguchi K, Ishii S, Shimizu T (2003). "Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family". J. Biol. Chem. 278 (28): 25600–6. doi:10.1074/jbc.M302648200. PMID 12724320.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.