LMO4

LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.^[5]

LMO4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L4Z
Identifiers
Aliases	LMO4, LIM domain only 4
External IDs	OMIM: 603129; MGI: 109360; HomoloGene: 4927; GeneCards: LMO4; OMA:LMO4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 87,328,880 bp[1] End 87,348,923 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 H2|3 68.61 cM Start 143,894,291 bp[2] End 143,910,981 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in dorsolateral prefrontal cortex prefrontal cortex Brodmann area 46 superior frontal gyrus parietal lobe postcentral gyrus Brodmann area 9 frontal pole cingulate gyrus anterior cingulate cortex Top expressed in granulocyte genital tubercle cingulate gyrus superior frontal gyrus visual cortex primary motor cortex primary visual cortex dentate gyrus of hippocampal formation granule cell CA3 field corneal stroma More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity metal ion binding protein binding cis-regulatory region sequence-specific DNA binding transcription factor binding Cellular component transcription regulator complex cell leading edge Biological process regulation of transcription, DNA-templated ventricular septum development spinal cord association neuron differentiation thymus development negative regulation of protein-containing complex assembly transcription, DNA-templated ventral spinal cord interneuron differentiation regulation of cell activation spinal cord motor neuron differentiation regulation of cell fate specification positive regulation of transcription by RNA polymerase II neural tube closure transcription by RNA polymerase II positive regulation of kinase activity regulation of cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8543 16911 Ensembl ENSG00000143013 ENSMUSG00000028266 UniProt P61968 P61969 RefSeq (mRNA) NM_006769 NM_001369491 NM_001161769 NM_001161770 NM_010723 RefSeq (protein) NP_006760 NP_001356420 NP_001155241 NP_001155242 NP_034853 Location (UCSC) Chr 1: 87.33 – 87.35 Mb Chr 3: 143.89 – 143.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.^[5]

Clinical Significance

LMO4 has garnered significant attention for its involvement in cancer, particularly breast cancer.^[6] It is overexpressed in a substantial percentage of primary breast carcinomas.^[7] Studies have shown that LMO4 can promote the proliferation of mammary epithelial cells, inhibit their differentiation, and enhance cell invasion and motility, all of which are hallmarks of cancer progression.

Interactions

LMO4 has been shown to interact with LDB1,^[8][9] RBBP8^[8][10] and BRCA1.^[8][10]