LIN28B (gene)

Lin-28 homolog B is a protein that in humans is encoded by the LIN28B gene. ^[5]

LIN28B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4A4I
Identifiers
Aliases	LIN28B, CSDD2, lin-28 homolog B
External IDs	OMIM: 611044; MGI: 3584032; HomoloGene: 47607; GeneCards: LIN28B; OMA:LIN28B - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q16.3-q21 Start 104,936,616 bp[1] End 105,083,332 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B2 Start 45,252,716 bp[2] End 45,362,491 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta buccal mucosa cell gonad testicle secondary oocyte sperm decidua Brodmann area 23 right testis left testis Top expressed in tail of embryo zygote secondary oocyte embryo embryo primary oocyte genital tubercle spermatocyte epiblast morula More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding zinc ion binding protein binding metal ion binding RNA binding nucleic acid binding Cellular component cytoplasm nucleus nucleolus cytosol Biological process pre-miRNA processing miRNA catabolic process gene silencing regulation of transcription, DNA-templated RNA 3'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 389421 380669 Ensembl ENSG00000187772 ENSMUSG00000063804 UniProt Q6ZN17 Q45KJ6 RefSeq (mRNA) NM_001004317 NM_001031772 NM_001033152 RefSeq (protein) NP_001004317 NP_001026942 Location (UCSC) Chr 6: 104.94 – 105.08 Mb Chr 10: 45.25 – 45.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.

References

1. GRCh38: Ensembl release 89: ENSG00000187772 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063804 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Lin-28 homolog B". Retrieved 2016-03-06.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.