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Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.[3][4]
LILRB5 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | LILRB5, CD85C, LIR-8, LIR8, leukocyte immunoglobulin like receptor B5 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 604814; HomoloGene: 134027; GeneCards: LILRB5; OMA:LILRB5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.[4]
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