LILRB3

Leukocyte immunoglobulin-like receptor subfamily B member 3 is a protein that in humans is encoded by the LILRB3 gene.^[4][5][6]

LILRB3
Identifiers
Aliases	LILRB3, CD85A, HL9, ILT-5, ILT5, LILRA6, LIR-3, LIR3, PIRB, PIR-B, leukocyte immunoglobulin like receptor B3
External IDs	OMIM: 604820; MGI: 1195974; HomoloGene: 134028; GeneCards: LILRB3; OMA:LILRB3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,216,278 bp[1] End 54,223,506 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte monocyte spleen upper lobe of left lung appendix right lung bone marrow bone marrow cells right coronary artery n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding transmembrane signaling receptor activity amyloid-beta binding signaling receptor activity Cellular component membrane integral component of membrane integral component of plasma membrane plasma membrane secretory granule membrane Biological process immune system process adaptive immune response defense response cell surface receptor signaling pathway negative regulation of osteoclast differentiation neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11025 18729 Ensembl ENSG00000275019 ENSG00000274587 ENSG00000277816 ENSG00000204577 n/a UniProt Q6PI73 O75022 n/a RefSeq (mRNA) NM_001081450 NM_006864 NM_001320960 NM_001289428 NM_008848 NM_011093 RefSeq (protein) XP_006726238.1 XP_006726376 XP_006726377 XP_011546876 XP_011546877 n/a Location (UCSC) Chr 19: 54.22 – 54.22 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells and is believed to be a myeloid checkpoint. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]

See also

• Cluster of differentiation