LILRA3

Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the leukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown; however, it is highly homologous to other LILR genes,^[2] and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.^[3][4][5]

LILRA3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3Q2C
Identifiers
Aliases	LILRA3, CD85E, HM31, HM43, ILT-6, ILT6, LIR-4, LIR4, leukocyte immunoglobulin like receptor A3
External IDs	OMIM: 604818; GeneCards: LILRA3; OMA:LILRA3 - orthologs
RNA expression pattern Bgee Human Mouse (ortholog) n/a n/a BioGPS More reference expression data
Gene ontology Molecular function antigen binding signaling receptor activity Cellular component extracellular region plasma membrane specific granule membrane tertiary granule membrane ficolin-1-rich granule membrane Biological process defense response adaptive immune response signal transduction immune system process neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11026 n/a Ensembl n/a n/a UniProt Q8N6C8 n/a RefSeq (mRNA) NM_001172654 NM_006865 n/a RefSeq (protein) NP_001166125 NP_006856 n/a Location (UCSC) n/a n/a PubMed search [1] n/a
Wikidata
View/Edit Human

Like the closely related LILRA1, LILRA3 binds to both normal and 'unfolded' free heavy chains of HLA class I, with a preference for free heavy chains of HLA-C alleles ^[6]

See also

• Cluster of differentiation

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. Torkar M, Haude A, Milne S, Beck S, Trowsdale J, Wilson MJ (December 2000). "Arrangement of the ILT gene cluster: a common null allele of the ILT6 gene results from a 6.7-kbp deletion". European Journal of Immunology. 30 (12): 3655–62. doi:10.1002/1521-4141(200012)30:12<3655::aid-immu3655>3.0.co;2-y. PMID 11169408. S2CID 38450831.
3. Arm JP, Nwankwo C, Austen KF (September 1997). "Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor". Journal of Immunology. 159 (5): 2342–9. doi:10.4049/jimmunol.159.5.2342. PMID 9278324. S2CID 45021877.
4. Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (December 1997). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". Journal of Immunology. 159 (11): 5192–6. doi:10.4049/jimmunol.159.11.5192. PMID 9548455. S2CID 36907307.
5. "Entrez Gene: LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3".
6. Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL (March 2011). "HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding". Journal of Immunology. 186 (5): 2990–7. doi:10.4049/jimmunol.1003078. PMID 21270408.

Further reading

• Samaridis J, Colonna M (March 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". European Journal of Immunology. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806. S2CID 2212182.
• Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (May 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". The Journal of Experimental Medicine. 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.
• Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M (December 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.
• Wiśniewski A, Łuszczek W, Mańczak M, Jasek M, Kubicka W, Cislo M, Kuśnierczyk P (April 2003). "Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls". Human Immunology. 64 (4): 458–61. doi:10.1016/S0198-8859(03)00025-9. PMID 12651072.
• Norman PJ, Carey BS, Stephens HA, Vaughan RW (June 2003). "DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3". Immunogenetics. 55 (3): 165–71. doi:10.1007/s00251-003-0561-1. PMID 12750859. S2CID 52863887.
• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.

External links

• LILRA3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q8N6C8 (Leukocyte immunoglobulin-like receptor subfamily A member 3) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.