LGI2

Leucine-rich repeat LGI family member 2 is a protein that in humans is encoded by the LGI2 gene.^[5][6][7]

LGI2
Identifiers
Aliases	LGI2, LGIL2, leucine-rich repeat LGI family member 2, leucine rich repeat LGI family member 2
External IDs	OMIM: 608301; MGI: 2180196; HomoloGene: 10048; GeneCards: LGI2; OMA:LGI2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 24,998,847 bp[1] End 25,030,946 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C1 Start 52,690,859 bp[2] End 52,723,804 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in smooth muscle tissue left uterine tube gastric mucosa tibial nerve right coronary artery left coronary artery gallbladder appendix prefrontal cortex body of uterus Top expressed in conjunctival fornix iris deep cerebellar nuclei pontine nuclei medial vestibular nucleus inferior colliculi substantia nigra facial motor nucleus ciliary body dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 55203 246316 Ensembl ENSG00000153012 ENSMUSG00000039252 UniProt Q8N0V4 Q8K4Z0 RefSeq (mRNA) NM_018176 NM_144945 NM_001310604 RefSeq (protein) NP_060646 NP_001297533 NP_659194 Location (UCSC) Chr 4: 25 – 25.03 Mb Chr 5: 52.69 – 52.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000153012 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039252 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gu W, Wevers A, Schroder H, Grzeschik KH, Derst C, Brodtkorb E, de Vos R, Steinlein OK (May 2002). "The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins". FEBS Lett. 519 (1–3): 71–6. doi:10.1016/S0014-5793(02)02713-8. PMID 12023020. S2CID 41639083.
6. Gu W, Gibert Y, Wirth T, Elischer A, Bloch W, Meyer A, Steinlein OK, Begemann G (Oct 2005). "Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders". Mol Biol Evol. 22 (11): 2209–16. doi:10.1093/molbev/msi214. hdl:10536/DRO/DU:30063551. PMID 16014869.
7. "Entrez Gene: LGI2 leucine-rich repeat LGI family, member 2".

Further reading

• Staub E, Pérez-Tur J, Siebert R, et al. (2002). "The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders". Trends Biochem. Sci. 27 (9): 441–4. doi:10.1016/S0968-0004(02)02163-1. PMID 12217514.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
• Scheel H, Tomiuk S, Hofmann K (2003). "A common protein interaction domain links two recently identified epilepsy genes". Hum. Mol. Genet. 11 (15): 1757–62. doi:10.1093/hmg/11.15.1757. PMID 12095917.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519. S2CID 6644433.