Loading AI tools
South Korean biologist From Wikipedia, the free encyclopedia
Dr. Kim Sunghoon is a South Korean biologist.
Sunghoon Kim | |
---|---|
Born | 1958 (age 65–66) South Korea |
Nationality | South Korean |
Alma mater | Ph.D. Brown University, U.S. |
Known for | Aminoacyl-tRNA Synthetases |
Awards | Korea Science Award, Ministry of Science and Technology (2003) Scientist of the Month, Korea Science and Engineering Foundation (KOSEF) (2003) Top Scientist and Technologist Award of Korea, Ministry of Science and Technology (2006) Award of Korean National Academy of Science (2012) |
Scientific career | |
Fields | Aminoacyl-tRNA synthetase, Translation, Cancer biology, Therapeutic target discovery |
Institutions | Seoul National University |
Doctoral advisor | Dr. Arthur Landy |
Korean name | |
Hangul | 김성훈 |
Revised Romanization | Kim Seong-hun |
McCune–Reischauer | Kim Sŏnghun |
![]() |
Dr. Sunghoon Kim has been studying novel functions of human aminoacyl-tRNA synthetases (ARSs) and searching for their pathophysiological connections to human diseases (PNAS 105:11043,[1] 2008; Nat Rev Cancer 11:708, 2011[2]). He has identified potent novel tumor suppressors such as AIMP2/p38 (Nat Genet 34:330, 2003[3]), AIMP3/p18 (Cell, 120:209, 2005[4]). Besides, he has also investigated novel extracellular activities of ARSs and associated factors such as lysyl-tRNA synthetase (KRS) (PNAS 102, 6356, 2005[5]), tryptophanyl-tRNA synthetase(WRS)(Nat Struct Mol Biol 11:149, 2004[6]) and AIMP1/p43 (PNAS 103:14913, 2006[7]). He also discovered the oncogenic variant of AIMP2, designated AIMP2-DX2, as one of the critical factors that determines the survival of lung cancer patients (Plos Genet 7:e1001351, 2011[8]). More recently[when?], he found that leucyl-tRNA synthetase (LRS) serves as an amino acid sensor for mTOR signal pathway (Cell 149:410, 2012[9]).
In summary, his research is unveiling novel regulatory network mediated by human aminoacyl-tRNA synthetases that have been regarded as housekeeping machinery for protein synthesis. The regulatory roles and implications of these proteins in human diseases have been largely overlooked for decades. His series of the discoveries on the new function, pathology and medicine of ARSs are rapidly opening a research area that throws new insights into the central dogma of life and human diseases.
Seamless Wikipedia browsing. On steroids.
Every time you click a link to Wikipedia, Wiktionary or Wikiquote in your browser's search results, it will show the modern Wikiwand interface.
Wikiwand extension is a five stars, simple, with minimum permission required to keep your browsing private, safe and transparent.