KatG

KatG is an enzyme that functions as both catalase and peroxidase. In Mycobacterium tuberculosis, mutations in KatG are commonly associated with resistance to the antibiotic drug isoniazid, which targets the mycolic acids within M. tuberculosis, and more general multi-drug resistance.^[1][2] Due to both its catalase and peroxidase activity, this enzyme protects M. tuberculosis against reactive oxygen species. M. tuberculosis' survival within macrophages depends on the KatG enzyme.^[3][4]