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Kane is a surname of English or Irish origin. In England, it is derived from the old English name (k)cana.[1] In Ireland however, the name is of different origins as an anglicisation of Mac Catháin, and in Scotland, a sept of Clan MacMillan.
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- Adelaide Kane, Australian actress
- Amory Kane, American composer and musician
- Art Kane, fashion and music photographer (who created the 1958 portrait of 57 jazz musicians, A Great Day in Harlem)
- Arthur Kane, American bassist of the New York Dolls
- Barbara Sanchez-Kane, Mexican fashion designer
- Ben Kane, English novelist, specialising in historical fiction.
- Ben Kane (record producer), American record producer
- Big Daddy Kane, American rapper
- Bob Kane, most famous as the co-creator of Batman
- Candye Kane (1965–2016), American blues and jazz performer
- Carol Kane, American actress
- Chelsea Kane, American actress and singer, originally known as Chelsea Staub
- Chris Kane, Australian guitarist and songwriter of Eye of the Enemy
- Christian Kane, American actor and country musician
- Christopher Kane, Scottish fashion designer
- Clinton Kane (born 1998/1999), Australian singer, songwriter, and musician
- David Kane (pianist), US/Scottish composer and jazz pianist
- Eden Kane (born 1940), British singer
- Gil Kane, comic book artist
- Greg Kane (musician) (born 1966), Scottish musician, and co-member of Hue and Cry
- Cheikh Hamidou Kane, Senegalese writer.
- Harry Kane (illustrator) (1912–1988), American illustrator and artist
- Henry B. Kane (1902–1971), American illustrator, photographer, and author of nature books for children
- Herb Kawainui Kane, artist-historian and author.
- John Kane (artist), Scottish painter
- Joseph Kane, U.S. film director and producer
- Justin Kane, American actor
- Kevin Kane (musician), Canadian songwriter
- Kimberly Kane, American pornographic actress
- Miles Kane, British singer
- Phil Kane, Scottish keyboard player of The Silencers
- Samuel Kane (born 1968), British actor
- Sarah Kane, English playwright
- Thommy Kane, Actor, filmmaker, Songwriter and composer
- Tom Kane, American voice actor
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- Ben Kane (footballer), Australian Australian rules footballer
- Boyd Kane, hockey player for the AHL's Hershey Bears
- DeAndre Kane, American basketball player in the Israeli Premier League and EuroLeague
- Evander Kane, hockey player for the NHL's Edmonton Oilers
- George Francis Kane (born 1948), American chess master
- Harry Kane (born 1993), English footballer
- Harry Kane (baseball) (1883–1932), American baseball player
- Harry Kane (hurdler) (born 1933), British hurdler
- Herbie Kane (born 1998), English footballer
- Jim Kane (disambiguation), multiple people
- Justin Kane, Australian boxer
- Patrick Kane, hockey player for the NHL's Detroit Red Wings
- Rick Kane (1954–2009), NFL running back played for the Detroit Lions and Washington Redskins
- Sanoussi Kane (born 2001), American football player
- Stanley Kane, English footballer
- Todd Kane, English footballer
- Tony Kane, Irish footballer
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- Elisha Kent Kane, medical officer in the United States Navy during the first half of the 19th century, member of two arctic expeditions
- Elizabeth Kane (1836-1909), American physician, writer, philanthropist, and women's rights activist. Married to Thomas L. Kane
- Frank E. Kane (born 1932), Canadian politician
- James Kane (1895–1964), Australian politician
- Kathleen Kane (born 1966), Pennsylvania lawyer and former attorney general convicted of felony perjury
- Michael N. Kane (1851–1924), American lawyer, judge, and politician
- Richard Rutledge Kane, Resident Commissioner of the Solomon Islands Protectorate
- Thomas L. Kane (1822–1883), American Civil War general and founder of Kane, Pennsylvania. Married to Elizabeth Kane.
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- Charles L. Kane, American theoretical physicist
- Daniel Kane (linguist), Australian linguist, expert on Jurchen and Khitan languages
- Daniel Kane (mathematician) (born 1986), American mathematician
- Josephine Kane, British academic and historian of architecture
- Pandurang Vaman Kane (1880–1972), Sanskrit scholar and an awardee of the Bharat Ratna
- Ruth Kane, New Zealand professor of education
- Thomas R. Kane, American academic
- Evan O'Neill Kane (1861–1932), surgeon who performed several self-operations
- Gordon L. Kane, scientific leader in theoretical and phenomenological particle physics
- Jasper H. Kane, (1903–2004), American biochemist
- Katherine Sophia Kane (1811–1886), Irish botanist
- Shanley Kane, American technology writer
- Suzanne Amador Kane, American scientist
- Agnes Kane Callum (1925–2015), American genealogist
- Carol Kane (businesswoman), co-founder and joint CEO of Boohoo.com
- Nichola Kane, Scottish broadcast journalist
- Kane (noble family), a Norwegian noble family
- Vincent Kane, British news reporter
- Adam Kane, protagonist in one of Dead Rising 3 expansion missions.
- Barry Kane from Saboteur
- Bette Kane, or Betty Kane, the DC Comics Pre-Crisis Bat-Girl
- Billy Kane, a video game character created by SNK Playmore, appearing in the Fatal Fury and The King of Fighters series
- Carter and Sadie Kane, protagonists from the series The Kane Chronicles by Rick Riordan
- Charles Foster Kane from Citizen Kane
- Erica Kane, fictional character from the American television soap opera All My Children
- Fergus K. Kane from Lady in the Lake
- Garrison Kane, comic book character from the Marvel Universe
- Gilbert Kane, character in the film Alien
- Reverend Henry Kane, fictional character from the Poltergeist film trilogy
- John Kane, a fictional character who appeared in a number of episodes of "So Weird", portrayed by Canadian-British actor Mackenzie Gray
- John Michael Kane, one of the aliases of Jason Bourne in the Bourne Identity by Robert Ludlum
- Kathy/Kate Kane, Batwoman
- Lucas Kane, protagonist of the video game Fahrenheit a.k.a. Indigo Prophecy
- Marcus Kane from The 100 (TV series)
- Marshall Kane from Community
- Matthew Kane, the protagonist of the computer game Quake 4
- Needles Kane, character in the video game series Twisted Metal originally developed by Singletrac
- Solomon Kane, fictional 16th century Puritan adventurer created by Robert E. Howard
- Will Kane from High Noon
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