KLF14

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

KLF14

Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene.[5] The corresponding Klf14 mouse gene is known as Sp6.[6]

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KLF14
Identifiers
AliasesKLF14, BTEB5, Kruppel-like factor 14, Kruppel like factor 14
External IDsOMIM: 609393; MGI: 3577024; HomoloGene: 76469; GeneCards: KLF14; OMA:KLF14 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138693

NM_001135093

RefSeq (protein)

NP_619638

NP_001128565

Location (UCSC)Chr 7: 130.73 – 130.73 MbChr 6: 30.93 – 30.94 Mb
PubMed search[3][4]
Wikidata
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Function

KLF14 is a member of the Krüppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGFβRII (the type II receptor for TGFβ).[7] KLF14 is expressed in many tissues,[8] lacks introns, and is subject to parent-specific expression.[9]

KLF14 appears to be a master regulator of gene expression in adipose tissue.[10]

Protein structure

Like the other members of the KLF family, KLF14 has three zinc-finger domains near the C-terminus, all three of which are of the classical C2H2 type. In the human, they are at amino acids 195–219, 225–249, and 255–277.[11]

Human KLF14 is 323 amino acids in length, with a molecular weight of 33,124;[11] in the mouse its length is 325.[12]

Clinical significance

There appears to be a connection between KLF14 and coronary artery disease, hypercholesterolemia and type 2 diabetes.[13][14]

References

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