KLF14

Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene.^[5] The corresponding Klf14 mouse gene is known as Sp6.^[6]

KLF14
Identifiers
Aliases	KLF14, BTEB5, Kruppel-like factor 14, Kruppel like factor 14
External IDs	OMIM: 609393; MGI: 3577024; HomoloGene: 76469; GeneCards: KLF14; OMA:KLF14 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.2 Start 130,730,697 bp[1] End 130,734,207 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 A3.3 Start 30,932,958 bp[2] End 30,936,013 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle right adrenal cortex left adrenal gland left adrenal cortex muscle of thigh gastrocnemius muscle subcutaneous adipose tissue skeletal muscle tissue smooth muscle tissue Top expressed in Pituitary Gland yolk sac lumbar subsegment of spinal cord embryo umbilical cord internal carotid artery condyle epididymis fossa efferent ductule More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific chromatin binding Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of sphingolipid mediated signaling pathway regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 136259 619665 Ensembl ENSG00000266265 ENSMUSG00000073209 UniProt Q8TD94 Q19A41 RefSeq (mRNA) NM_138693 NM_001135093 RefSeq (protein) NP_619638 NP_001128565 Location (UCSC) Chr 7: 130.73 – 130.73 Mb Chr 6: 30.93 – 30.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

KLF14 is a member of the Krüppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGFβRII (the type II receptor for TGFβ).^[7] KLF14 is expressed in many tissues,^[8] lacks introns, and is subject to parent-specific expression.^[9]

KLF14 appears to be a master regulator of gene expression in adipose tissue.^[10]

Protein structure

Like the other members of the KLF family, KLF14 has three zinc-finger domains near the C-terminus, all three of which are of the classical C₂H₂ type. In the human, they are at amino acids 195–219, 225–249, and 255–277.^[11]

Human KLF14 is 323 amino acids in length, with a molecular weight of 33,124;^[11] in the mouse its length is 325.^[12]

Clinical significance

There appears to be a connection between KLF14 and coronary artery disease, hypercholesterolemia and type 2 diabetes.^[13][14]

References

1. GRCh38: Ensembl release 89: ENSG00000266265 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073209 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Klf14 Kruppel-like factor 14 [Mus musculus] - Gene result".
6. "Sp6 trans-acting transcription factor 6 [Mus musculus] - Gene result".
7. Truty MJ, Lomberk G, Fernandez-Zapico ME, Urrutia R (Mar 2009). "Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling". The Journal of Biological Chemistry. 284 (10): 6291–300. doi:10.1074/jbc.M807791200. PMC 2649086. PMID 19088080.
8. Swamynathan SK (Apr 2010). "Krüppel-like factors: three fingers in control". Human Genomics. 4 (4): 263–70. doi:10.1186/1479-7364-4-4-263. PMC 2975451. PMID 20511139.
9. Parker-Katiraee L, Carson AR, Yamada T, Arnaud P, Feil R, Abu-Amero SN, Moore GE, Kaneda M, Perry GH, Stone AC, Lee C, Meguro-Horike M, Sasaki H, Kobayashi K, Nakabayashi K, Scherer SW (May 2007). "Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution". PLOS Genetics. 3 (5): e65. doi:10.1371/journal.pgen.0030065. PMC 1865561. PMID 17480121.
10. Small KS, Hedman AK, Grundberg E, Nica AC, Thorleifsson G, Kong A, Thorsteindottir U, Shin SY, Richards HB, Soranzo N, Ahmadi KR, Lindgren CM, Stefansson K, Dermitzakis ET, Deloukas P, Spector TD, McCarthy MI (Jun 2011). "Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes". Nature Genetics. 43 (6): 561–4. doi:10.1038/ng.833. PMC 3192952. PMID 21572415.
11. "Krüppel-like factor 14". Human Protein Reference Database. Johns Hopkins University. Archived from the original on April 15, 2013. Retrieved 2011-05-18.
12. Online Mendelian Inheritance in Man (OMIM): Krüppel-like factor 14 - 609393
13. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, et al. (Jul 2010). "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis". Nature Genetics. 42 (7): 579–89. doi:10.1038/ng.609. PMC 3080658. PMID 20581827.
14. Grarup N, Sparsø T, Hansen T (Dec 2010). "Physiologic characterization of type 2 diabetes-related loci". Current Diabetes Reports. 10 (6): 485–97. doi:10.1007/s11892-010-0154-y. PMC 2955912. PMID 20886378.

External links

• Huffington Post: Scientists Find Genetic 'Switch' For Obesity