KCNS2

Potassium voltage-gated channel subfamily S member 2 is a protein that in humans is encoded by the KCNS2 gene.^[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[5][6]

KCNS2
Identifiers
Aliases	KCNS2, KV9.2, potassium voltage-gated channel modifier subfamily S member 2
External IDs	OMIM: 602906; MGI: 1197011; HomoloGene: 22465; GeneCards: KCNS2; OMA:KCNS2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.2 Start 98,426,958 bp[1] End 98,432,853 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 34,837,501 bp[2] End 34,843,553 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell middle temporal gyrus Brodmann area 23 primary visual cortex prefrontal cortex buccal mucosa cell Brodmann area 9 superior frontal gyrus right frontal lobe Parietal Lobe Top expressed in medial dorsal nucleus habenula dorsal striatum olfactory tubercle substantia nigra nucleus accumbens anterior amygdaloid area lumbar subsegment of spinal cord lateral geniculate nucleus piriform cortex More reference expression data BioGPS n/a
Gene ontology Molecular function ion channel activity potassium channel activity protein binding voltage-gated ion channel activity voltage-gated potassium channel activity Cellular component perinuclear region of cytoplasm integral component of membrane voltage-gated potassium channel complex plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport regulation of delayed rectifier potassium channel activity protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3788 16539 Ensembl ENSG00000156486 ENSMUSG00000050963 UniProt Q9ULS6 O35174 RefSeq (mRNA) NM_020697 NM_001271704 NM_181317 NM_008436 RefSeq (protein) NP_065748 NP_001258633 NP_851834 Location (UCSC) Chr 8: 98.43 – 98.43 Mb Chr 15: 34.84 – 34.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000156486 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050963 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M (Oct 1997). "New modulatory alpha subunits for mammalian Shab K+ channels". J Biol Chem. 272 (39): 24371–9. doi:10.1074/jbc.272.39.24371. PMID 9305895.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

Further reading

• Banfi S, Borsani G, Rossi E, et al. (1996). "Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching". Nat. Genet. 13 (2): 167–74. doi:10.1038/ng0696-167. PMID 8640222. S2CID 38441640.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hirosawa M, Nagase T, Ishikawa K, et al. (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• Kv9.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNS2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)