KCNS1

Potassium voltage-gated channel subfamily S member 1 is a protein that in humans is encoded by the KCNS1 gene.^[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[5][6]

KCNS1
Identifiers
Aliases	KCNS1, KV9.1, potassium voltage-gated channel modifier subfamily S member 1
External IDs	OMIM: 602905; MGI: 1197019; HomoloGene: 20517; GeneCards: KCNS1; OMA:KCNS1 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,091,214 bp[1] End 45,101,127 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,005,539 bp[2] End 164,013,033 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 primary visual cortex cardia Brodmann area 46 superior frontal gyrus postcentral gyrus orbitofrontal cortex spinal ganglia ventral tegmental area Top expressed in lumbar spinal ganglion parotid gland superior frontal gyrus primary visual cortex calvaria embryo embryo dentate gyrus of hippocampal formation granule cell entorhinal cortex primary motor cortex More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated potassium channel activity ion channel activity potassium channel regulator activity potassium channel activity protein binding delayed rectifier potassium channel activity voltage-gated ion channel activity Cellular component integral component of membrane membrane voltage-gated potassium channel complex plasma membrane perinuclear region of cytoplasm Biological process regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport regulation of delayed rectifier potassium channel activity potassium ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3787 16538 Ensembl ENSG00000124134 ENSMUSG00000040164 UniProt Q96KK3 O35173 RefSeq (mRNA) NM_002251 NM_001322799 NM_008435 RefSeq (protein) NP_001309728 NP_002242 NP_032461 Location (UCSC) Chr 20: 45.09 – 45.1 Mb Chr 2: 164.01 – 164.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000124134 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040164 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M (Oct 1997). "New modulatory alpha subunits for mammalian Shab K+ channels". J Biol Chem. 272 (39): 24371–9. doi:10.1074/jbc.272.39.24371. PMID 9305895.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shepard AR, Rae JL (1999). "Electrically silent potassium channel subunits from human lens epithelium". Am. J. Physiol. 277 (3 Pt 1): C412–24. doi:10.1152/ajpcell.1999.277.3.C412. PMID 10484328.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID 11549316.
• Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.

External links

• Kv9.1+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNS1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)