KCNK18

Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K_2P18.1 is a protein that in humans is encoded by the KCNK18 gene. K_2P18.1 is a potassium channel containing two pore-forming P domains.^[5]

KCNK18
Identifiers
Aliases	KCNK18, K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK, potassium two pore domain channel subfamily K member 18
External IDs	OMIM: 613655; MGI: 2685627; HomoloGene: 133808; GeneCards: KCNK18; OMA:KCNK18 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.3 Start 117,197,489 bp[1] End 117,210,299 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D3 Start 59,207,646 bp[2] End 59,225,806 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens caudate nucleus prefrontal cortex hypothalamus renal cortex anterior cingulate cortex Top expressed in zygote secondary oocyte primary oocyte embryo placenta More reference expression data BioGPS n/a
Gene ontology Molecular function calcium-activated potassium channel activity outward rectifier potassium channel activity potassium channel activity potassium ion leak channel activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process potassium ion transport cellular response to pH ion transport potassium ion transmembrane transport stabilization of membrane potential potassium ion export across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338567 332396 Ensembl ENSG00000186795 ENSMUSG00000040901 UniProt Q7Z418 Q6VV64 RefSeq (mRNA) NM_181840 NM_207261 RefSeq (protein) NP_862823 NP_997144 Location (UCSC) Chr 10: 117.2 – 117.21 Mb Chr 19: 59.21 – 59.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

A flaw in this gene could help trigger migraine headaches. If the gene does not work properly, environmental factors can more easily trigger pain centres in the brain and cause a severe headache.^[6]

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000186795 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040901 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
6. Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, Pereira-Monteiro JM, Griffiths LR, Tucker SJ, Ebers G, Rouleau GA (September 2010). "A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura". Nature Medicine. 16 (10): 1157–1160. doi:10.1038/nm.2216. PMID 20871611. S2CID 205387180.

   • "Migraine cause 'identified' as genetic defect". BBC News. 2010-09-27.

Further reading

• Andres-Enguix I, Shang L, Stansfeld PJ, Morahan JM, Sansom MS, Lafrenière RG, Roy B, Griffiths LR, Rouleau GA, Ebers GC, Cader MZ, Tucker SJ (2012). "Functional analysis of missense variants in the TRESK (KCNK18) K+ channel". Scientific Reports. 2. article number 237. doi:10.1038/srep00237. PMC 3266952. PMID 22355750.
• Czirják G, Tóth ZE, Enyedi P (2004). "The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin". J. Biol. Chem. 279 (18): 18550–8. doi:10.1074/jbc.M312229200. PMID 14981085.
• Kang D, Mariash E, Kim D (2004). "Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family". J. Biol. Chem. 279 (27): 28063–70. doi:10.1074/jbc.M402940200. PMID 15123670.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Czirják G, Vuity D, Enyedi P (2008). "Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation". J. Biol. Chem. 283 (23): 15672–80. doi:10.1074/jbc.M800712200. PMC 3259650. PMID 18397886.
• Pottosin II, Bonales-Alatorre E, Valencia-Cruz G, et al. (2008). "TRESK-like potassium channels in leukemic T cells". Pflügers Arch. 456 (6): 1037–48. doi:10.1007/s00424-008-0481-x. PMID 18506476. S2CID 3245155.
• Sano Y, Inamura K, Miyake A, et al. (2003). "A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord". J. Biol. Chem. 278 (30): 27406–12. doi:10.1074/jbc.M206810200. PMID 12754259.

External links

• KCNK18+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)