KCNK16

Potassium channel subfamily K member 16 is a protein that in humans is encoded by the KCNK16 gene.^[5][6] The protein encoded by this gene, K_2P16.1, is a potassium channel containing two pore-forming P domains.^[5][6]

KCNK16
Identifiers
Aliases	KCNK16, K2p16.1, TALK-1, TALK1, potassium two pore domain channel subfamily K member 16
External IDs	OMIM: 607369; MGI: 1921821; HomoloGene: 75328; GeneCards: KCNK16; OMA:KCNK16 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.2 Start 39,314,698 bp[1] End 39,322,968 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A3|14 Start 20,311,444 bp[2] End 20,319,267 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans body of pancreas duodenum body of stomach fundus left lobe of thyroid gland ascending aorta right lung right lobe of thyroid gland olfactory zone of nasal mucosa Top expressed in islet of Langerhans embryo yolk sac stomach lip hair follicle skin of abdomen lumbar spinal ganglion skin of back genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding voltage-gated ion channel activity potassium channel activity potassium ion leak channel activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport potassium ion transmembrane transport stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83795 74571 Ensembl ENSG00000095981 ENSMUSG00000023387 UniProt Q96T55 G5E845 RefSeq (mRNA) NM_001135105 NM_001135106 NM_001135107 NM_032115 NM_001363784 NM_029006 RefSeq (protein) NP_001128577 NP_001128578 NP_001128579 NP_115491 NP_001350713 NP_083282 Location (UCSC) Chr 6: 39.31 – 39.32 Mb Chr 14: 20.31 – 20.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000095981 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023387 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F (Mar 2001). "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels". Biochem Biophys Res Commun. 282 (1): 249–56. doi:10.1006/bbrc.2001.4562. PMID 11263999.
6. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

Further reading

• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
• Han J, Kang D, Kim D (2003). "Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1". Am. J. Physiol., Cell Physiol. 285 (3): C529–38. doi:10.1152/ajpcell.00601.2002. PMID 12724142. S2CID 23208697.
• Gierten J, Ficker E, Bloehs R, et al. (2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". Br. J. Pharmacol. 154 (8): 1680–90. doi:10.1038/bjp.2008.213. PMC 2518462. PMID 18516069.

External links

• KCNK16+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)