KCNH8

Potassium voltage-gated channel subfamily H member 8 is a protein that in humans is encoded by the KCNH8 gene.^[5] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[5]

KCNH8
Identifiers
Aliases	KCNH8, ELK, ELK1, Kv12.1, elk3, potassium voltage-gated channel subfamily H member 8
External IDs	OMIM: 608260; MGI: 2445160; HomoloGene: 14332; GeneCards: KCNH8; OMA:KCNH8 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p24.3 Start 19,148,510 bp[1] End 19,535,642 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 52,909,737 bp[2] End 53,286,222 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum endothelial cell C1 segment substantia nigra Pituitary Gland anterior pituitary putamen hippocampus proper testicle Amygdala Top expressed in otolith organ utricle Pituitary Gland habenula lumbar spinal ganglion vestibular sensory epithelium Rostral migratory stream ganglionic eminence suprachiasmatic nucleus trigeminal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated potassium channel activity ion channel activity phosphorelay sensor kinase activity potassium channel activity voltage-gated ion channel activity Cellular component integral component of membrane intracellular anatomical structure membrane integral component of plasma membrane plasma membrane Biological process phosphorelay signal transduction system regulation of membrane potential potassium ion transport regulation of ion transmembrane transport ion transport transmembrane transport signal transduction potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 131096 211468 Ensembl ENSG00000183960 ENSMUSG00000035580 UniProt Q96L42 P59111 RefSeq (mRNA) NM_144633 NM_001031811 RefSeq (protein) NP_653234 NP_001026981 Location (UCSC) Chr 3: 19.15 – 19.54 Mb Chr 17: 52.91 – 53.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000183960 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035580 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

Further reading

• Baxter DF, Kirk M, Garcia AF, et al. (2002). "A novel membrane potential-sensitive fluorescent dye improves cell-based assays for ion channels". Journal of Biomolecular Screening. 7 (1): 79–85. doi:10.1089/108705702753520369. PMID 11897058.
• Kiel DP, Demissie S, Dupuis J, et al. (2007). "Genome-wide association with bone mass and geometry in the Framingham Heart Study". BMC Med. Genet. 8 (Suppl 1): S14. doi:10.1186/1471-2350-8-S1-S14. PMC 1995606. PMID 17903296.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zou A, Lin Z, Humble M, et al. (2003). "Distribution and functional properties of human KCNH8 (Elk1) potassium channels". Am. J. Physiol., Cell Physiol. 285 (6): C1356–66. CiteSeerX 10.1.1.196.6556. doi:10.1152/ajpcell.00179.2003. PMID 12890647. S2CID 39591842.

External links

• Kv12.1+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNH8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)