KCNC2

Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene.^[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).^[7]

KCNC2
Identifiers
Aliases	KCNC2, KV3.2, potassium voltage-gated channel subfamily C member 2
External IDs	OMIM: 176256; MGI: 96668; HomoloGene: 71199; GeneCards: KCNC2; OMA:KCNC2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.1 Start 75,040,077 bp[1] End 75,209,839 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D2|10 60.3 cM Start 112,107,026 bp[2] End 112,302,929 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Brodmann area 9 cingulate gyrus anterior cingulate cortex right frontal lobe testicle Hypothalamus Amygdala Pituitary Gland hippocampus proper Top expressed in lateral geniculate nucleus medial geniculate nucleus medial dorsal nucleus inferior colliculi globus pallidus superior colliculus subiculum primary motor cortex piriform cortex medial vestibular nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function potassium channel activity transmembrane transporter binding voltage-gated ion channel activity ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity voltage-gated ion channel activity involved in regulation of presynaptic membrane potential Cellular component integral component of membrane vesicle perikaryon postsynaptic membrane cell projection membrane voltage-gated potassium channel complex plasma membrane synapse integral component of plasma membrane intracellular anatomical structure neuronal cell body membrane axon cell junction terminal bouton soma dendrite basolateral plasma membrane apical plasma membrane axolemma neuron projection presynaptic membrane dendrite membrane Biological process response to organic cyclic compound protein heterooligomerization regulation of insulin secretion response to nerve growth factor regulation of ion transmembrane transport cellular response to toxic substance response to magnesium ion ion transport globus pallidus development nitric oxide-cGMP-mediated signaling pathway potassium ion transport ion transmembrane transport transmembrane transport response to amine positive regulation of potassium ion transmembrane transport cellular response to nitric oxide response to light intensity response to ethanol protein homooligomerization response to toxic substance cellular response to ammonium ion potassium ion transmembrane transport positive regulation of voltage-gated potassium channel activity regulation of presynaptic membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3747 268345 Ensembl ENSG00000166006 ENSMUSG00000035681 UniProt Q96PR1 Q14B80 RefSeq (mRNA) NM_001260497 NM_001260498 NM_001260499 NM_139136 NM_139137 NM_153748 NM_001025581 NM_001359752 NM_001359753 NM_001379643 NM_001379644 RefSeq (protein) NP_001247426 NP_001247427 NP_001247428 NP_631874 NP_631875 NP_715624 NP_001020752 NP_001346681 NP_001346682 NP_001366572 NP_001366573 Location (UCSC) Chr 12: 75.04 – 75.21 Mb Chr 10: 112.11 – 112.3 Mb PubMed search [3] [4]
Wikidata
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Expression pattern

K_v3.1 and K_v3.2 channels are prominently expressed in neurons that fire at high frequency. K_v3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.^[8][9][7]

Physiological role

K_v3.1/K_v3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.^[9][10] Sometimes in heteromeric complexes with K_v3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.^[7][8]

Pharmacological properties

K_v3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC₅₀ values are 0.1 mM for both of the drugs).^[7][9] This can be useful in identifying native channels.^[9]

Transcript variants

There are four transcript variants of K_v3.2 gene: K_v3.2a, K_v3.2b, K_v3.2c, K_v3.2d. K_v3.2 isoforms differ only in their C-terminal sequence.^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000166006 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035681 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome. 4 (12): 711–5. doi:10.1007/BF00357794. PMID 8111118. S2CID 24121259.
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
7. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
8. Kolodin YO (2008-04-27). "Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat". Retrieved 2008-10-20.
9. Rudy B, McBain CJ (September 2001). "K_v3 channels: voltage-gated K⁺ channels designed for high-frequency repetitive firing". Trends in Neurosciences. 24 (9): 517–26. doi:10.1016/S0166-2236(00)01892-0. PMID 11506885. S2CID 36100588.
10. Lien CC, Jonas P (March 2003). "K_v3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons". Journal of Neuroscience. 23 (6): 2058–68. doi:10.1523/JNEUROSCI.23-06-02058.2003. PMC 6742035. PMID 12657664.
11. Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of K_v3 channels to neuronal excitability". Annals of the New York Academy of Sciences. 868 (1 MOLECULAR AND): 304–43. Bibcode:1999NYASA.868..304R. doi:10.1111/j.1749-6632.1999.tb11295.x. PMID 10414303. S2CID 25289187.

External links

• Kv3.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNC2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)