KCNA7

Potassium voltage-gated channel subfamily A member 7 also known as K_v1.7 is a protein that in humans is encoded by the KCNA7 gene.^[5] The protein encoded by this gene is a voltage-gated potassium channel subunit. It may contribute to the cardiac transient outward potassium current (I_to1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.^[6]

KCNA7
Identifiers
Aliases	KCNA7, HAK6, KV1.7, potassium voltage-gated channel subfamily A member 7
External IDs	OMIM: 176268; MGI: 96664; HomoloGene: 7791; GeneCards: KCNA7; OMA:KCNA7 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,067,397 bp[1] End 49,072,699 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 29.3 cM Start 45,055,077 bp[2] End 45,059,187 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis vastus lateralis muscle muscle of thigh Skeletal muscle tissue of biceps brachii gastrocnemius muscle deltoid muscle tibialis anterior muscle body of tongue apex of heart right auricle Top expressed in muscle of thigh skeletal muscle tissue quadriceps femoris muscle zone of skin lip esophagus embryo heart spermatocyte placenta More reference expression data BioGPS n/a
Gene ontology Molecular function ion channel activity potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3743 16495 Ensembl ENSG00000104848 ENSMUSG00000038201 UniProt Q96RP8 Q17ST2 RefSeq (mRNA) NM_031886 NM_010596 RefSeq (protein) NP_114092 NP_034726 Location (UCSC) Chr 19: 49.07 – 49.07 Mb Chr 7: 45.06 – 45.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000104848 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038201 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
6. Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72. doi:10.1006/jmcc.2001.1376. PMID 11343410.

Further reading

• Kashuba VI, Kvasha SM, Protopopov AI, et al. (2001). "Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family". Gene. 268 (1–2): 115–22. doi:10.1016/S0378-1119(01)00423-1. PMID 11368907.
• Kalman K, Nguyen A, Tseng-Crank J, et al. (1998). "Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7". J. Biol. Chem. 273 (10): 5851–7. doi:10.1074/jbc.273.10.5851. PMID 9488722.
• Ding Q, Zhao YY, Dong LY, et al. (2003). "[Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China]". Yi Chuan. 25 (2): 129–32. PMID 15639836.
• Bardien-Kruger S, Wulff H, Arieff Z, et al. (2002). "Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)". Eur. J. Hum. Genet. 10 (1): 36–43. doi:10.1038/sj.ejhg.5200739. PMID 11896454. S2CID 8333189.

External links

• Kv1.7+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNA7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)