Jpx (gene)

In molecular biology, JPX transcript, XIST activator (non-protein coding), also known as Jpx, is a long non-coding RNA. In humans, it is located on the X chromosome. It was identified during sequence analysis of the X inactivation centre, surrounding the Xist gene.^[3] Jpx upregulates expression of Xist.^[4]

JPX
Identifiers
Aliases	JPX, DCBALD06, ENOX, LINC00183, NCRNA00183, Jpx, JPX transcript, XIST activator (non-protein coding), JPX transcript, XIST activator
External IDs	OMIM: 300832; GeneCards: JPX; OMA:JPX - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.2 Start 73,944,182 bp[1] End 74,070,408 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon Achilles tendon right uterine tube bone marrow cells anterior pituitary internal globus pallidus C1 segment left ovary corpus callosum right ovary n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 554203 n/a Ensembl ENSG00000225470 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr X: 73.94 – 74.07 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

See also

• Long noncoding RNA

References

1. GRCh38: Ensembl release 89: ENSG00000225470 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Chureau C, Prissette M, Bourdet A, Barbe V, Cattolico L, Jones L, et al. (2002). "Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine". Genome Res. 12 (6): 894–908. doi:10.1101/gr.152902. PMC 1383731. PMID 12045143.
4. Tian D, Sun S, Lee JT (2010). "The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation". Cell. 143 (3): 390–403. doi:10.1016/j.cell.2010.09.049. PMC 2994261. PMID 21029862.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tsuritani K, Irie T, Yamashita R, et al. (2007). "Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes". Genome Res. 17 (7): 1005–1014. doi:10.1101/gr.6030107. PMC 1899111. PMID 17567985.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Kolesnikov NN, Elisafenko EA (2010). "[Comparative organization and the origin of noncoding regulatory RNA genes from X-chromosome inactivation center of human and mouse]". Genetika. 46 (10): 1386–1391. PMID 21254562.