John Roth (geneticist)

John Roger Roth (born 14 March 1939)^[2] is an American geneticist, bacterial physiologist, and evolutionist. He is a Distinguished Professor of Biological Sciences at the University of California, Davis.

John Roger Roth
Born	(1939-03-14) March 14, 1939 (age 85) Winona, Minnesota
Alma mater	Harvard University (BA) Johns Hopkins University (PhD) Umeå University (PhD Honoris Causa)
Occupation	Distinguished Professor of Biology
Spouse	Shery G. Roth
Awards	Genetics Society of America Thomas Hunt Morgan Medal (2009)[1] American Society for Microbiology Lifetime Achievement Award (2015)
Scientific career
Fields	DNA rearrangements Bacterial genetics evolution
Institutions	University of California, Berkeley University of Utah University of California, Davis
Doctoral advisor	Phil Hartman

He became well known for his early studies on the structure and regulation of the his operon of Salmonella,^[3] and went on to investigate regulation in systems as diverse as suppression by tRNA,^[4] NAD biosynthesis,^[5] and the Vitamin B12-dependent metabolism of small molecules such as ethanolamine and propanediol.^[6] In collaboration with David Botstein and Nancy Kleckner, he developed the use of transposons as genetic tools.^[7] As a by-product of his study of transposons, he developed an interest in chromosomal duplications, which are frequent in bacteria.^[8] He has recently authored several papers on the involvement of such small-effect mutations on evolution under selection.^[9]

As instructors of the summer Advanced Bacterial Genetics course at Cold Spring Harbor Laboratory, John Roth, David Botstein, and Ron Davis taught many scientists how to use transposons and other modern molecular genetic tools for analysis of bacteria, leading to important advances in our understanding of the genetics and physiology of bacteria.^[2]

In 1988, he became a member of the National Academy of Sciences.^[10] In 2009, he was awarded the Thomas Hunt Morgan Medal of the Genetics Society of America,^[1] and in 2015, the American Society for Microbiology Lifetime Achievement Award. In 2011, ASM Press published a festschrift in his honor ("The Lure of Bacterial Genetics: A Tribute to John Roth").^[2]

References

1. "Thomas Hunt Morgan Medal". Archived from the original on 2017-02-01. Retrieved 2011-10-13.
2. Maloy, S.; Hughes, K.T.; Casadesus, J., eds. (2011). The Lure of Bacterial Genetics: A Tribute to John Roth. Washington, DC: ASM Press. p. 362. ISBN 978-1-55581-538-7.
3. Johnston, M.; Barnes, W.; Chumley, F.; Bossi, L.; Roth, J.R. (1980). "Model for regulation of the histidine operon of Salmonella". Proc. Natl. Acad. Sci. USA. 77 (1): 508–512. Bibcode:1980PNAS...77..508J. doi:10.1073/pnas.77.1.508. PMC 348301. PMID 6987654.
4. Hartman, P.; Roth, J.R. (1973). Mechanisms of Suppression. Advances in Genetics. Vol. 17. pp. 1–105. doi:10.1016/S0065-2660(08)60170-4. ISBN 9780120176175. PMID 4585532.
5. Zhu, N.; Roth, J.R. (1991). "The nadI region of Salmonella typhimurium encodes a bifunctional regulatory protein". J. Bacteriol. 173 (3): 1302–1310. doi:10.1128/jb.173.3.1302-1310.1991. PMC 207255. PMID 1991723.
6. Roof, D.M.; Roth, J.R. (1992). "Autogenous regulation of ethanolamine utilization by a transcriptional activator of the eut operon in Salmonella typhimurium". J. Bacteriol. 174 (20): 6634–6643. doi:10.1128/jb.174.20.6634-6643.1992. PMC 207641. PMID 1328159.
7. Kleckner, N.; Botstein, D.; Roth, J.R. (1977). "Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics". J. Mol. Biol. 116 (1): 125–159. doi:10.1016/0022-2836(77)90123-1. PMID 338917.
8. Roth, J.R.; Benson, N.; Galitski, T.; Haack, K.; Lawrence, J.; Miesel, L. (1996). "Rearrangements of the bacterial chromosome: formation and applications". In Neidhardt, F.C.; Curtis, R. III; Ingraham, J.L.; Lin, E.C.C.; Low, K.B.; Magasanik, B.; Reznikoff, W.S.; Riley, M.; Schaechter, M.; Umbarger, H.E. (eds.). Escherichia coli and Salmonella: Cellular and Molecular Biology. Washington, DC: ASM Press. pp. 2256–2276. ISBN 978-1-55581-084-9.
9. Andersson, D.I.; Hughes, D.; Roth, J.R. (2011). "The origin of mutants under selection: interactions of mutation, growth, and selection, Chapter 5.6.6". In Finkel, S. (ed.). EcoSal -- Escherichia coli and Salmonella: Cellular and Molecular Biology. Vol. 10. Washington, DC: ASM Press.PDF
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