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Chemical compound From Wikipedia, the free encyclopedia
JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is the N-hexyl homolog of the more common synthetic cannabinoid compound JWH-018. Unlike the butyl homolog JWH-073, which is several times weaker than JWH-018, the hexyl homolog is only slightly less potent, although extending the chain one carbon longer to the heptyl homolog JWH-020 results in dramatic loss of activity. These results show that the optimum side chain length for CB1 binding in the naphthoylindole series is the five-carbon pentyl chain, shorter than in the classical cannabinoids where a seven-carbon heptyl chain produces the most potent compounds. This difference is thought to reflect a slightly different binding conformation adopted by the naphthoylindole compounds as compared to the classical cannabinoids, and may be useful in characterizing the active site of the CB1 and CB2 receptors.[2][3][4]
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| Formula | C25H25NO |
| Molar mass | 355.481 g·mol−1 |
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As of October 2015 JWH-019 is a controlled substance in China.[5]
In Poland, JWH-019 is I-N (Poland).[1]
JWH-019 is illegal in Sweden.
JWH-019 is Class B in the United Kingdom.
JWH-019 is a Schedule I controlled substance, controlled federally in the United States.[6]
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