Isogenous group

An isogenous group (lat. "equal origin") is a cluster of up to eight chondrocytes^[1] found in hyaline and elastic cartilage.^[2]

Micrograph of hyaline cartilage containing isogenous groups.

Formation

Chondrocytes develop in the embryo from mesenchymal progenitor cells through a process known as chondrogenesis.^[2][3] A chondrocyte can then undergo mitosis to form an isogenous group within its lacuna.^[3][4]

Function

Isogenous groups differentiate into individual chondrocytes where they continue to produce and deposit extracellular matrix (ECM), lengthening the cartilage and increasing its diameter.^[3][5] This is termed interstitial growth and is one of only two ways cartilage can grow.^[4]

Cartoon representation of hyaline cartilage with isogenous groups.

See also

• Endochondral ossification
• Hyaline