Isofentanyl

Isofentanyl (3-methyl-benzylfentanyl) is an opioid analgesic that is an analog (and structural isomer) of fentanyl first invented in 1973,^[2] and which has been sold as a designer drug.^[3]

Isofentanyl

Legal status
Legal status	US: Schedule I[1]
Identifiers
IUPAC name N-(1-Benzyl-3-methylpiperidin-4-yl)-N-phenylpropanamide
CAS Number	79278-40-3 Y
PubChem CID	10449690
ChemSpider	8625107
UNII	BT57ARH9QX
CompTox Dashboard (EPA)	DTXSID00747120
Chemical and physical data
Formula	C22H28N2O
Molar mass	336.479 g·mol−1
3D model (JSmol)	Interactive image
SMILES c2ccccc2N(C(=O)CC)C1CCN(CC1C)Cc3ccccc3

Side effects

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.^[4] A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week.^[5]

Legal status

As a structural isomer of fentanyl itself, isofentanyl is banned under drug analogue laws in many jurisdictions around the world. In the United States, fentanyl-related substances are Schedule I controlled substances.^[1]

See also

• 3-Methylfentanyl
• Benzylfentanyl
• α-Methylacetylfentanyl
• 4-Methylphenethylacetylfentanyl
• Homofentanyl
• Secofentanyl
• List of fentanyl analogues