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An interolog is a conserved interaction between a pair of proteins which have interacting homologs in another organism. The term was introduced in a 2000 paper by Walhout et al.[1][2]
Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins. Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold:
- A is a homolog of A'. (Protein homologs have similar amino acid sequences and derive from a common ancestral sequence).
- B is a homolog of B'.
- A and B interact.
- A' and B' interact.
Thus, interologs are homologous pairs of protein interactions across different organisms.
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