Interolog

An interolog is a conserved interaction between a pair of proteins which have interacting homologs in another organism. The term was introduced in a 2000 paper by Walhout et al.^[1][2]

Example

Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins. Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold:

• A is a homolog of A'. (Protein homologs have similar amino acid sequences and derive from a common ancestral sequence).
• B is a homolog of B'.
• A and B interact.
• A' and B' interact.

Thus, interologs are homologous pairs of protein interactions across different organisms.

See also

• Homology (biology)
• Systems biology
• Bioinformatics

References

1. Walhout, A. J.; Sordella, R.; Lu, X.; Hartley, J. L.; Temple, G. F.; Brasch, M. A.; Thierry-Mieg, N.; Vidal, M. (2000). "Protein Interaction Mapping in C. Elegans Using Proteins Involved in Vulval Development". Science. 287 (5450): 116–122. Bibcode:2000Sci...287..116W. doi:10.1126/science.287.5450.116. PMID 10615043.
2. Yu, H.; Luscombe, N. M.; Lu, H. X.; Zhu, X.; Xia, Y.; Han, J. D.; Bertin, N.; Chung, S.; Vidal, M.; Gerstein, M. (2004). "Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs". Genome Research. 14 (6): 1107–1118. doi:10.1101/gr.1774904. PMC 419789. PMID 15173116.

• Yu, H.; Luscombe, N. M.; Lu, H. X.; Zhu, X.; Xia, Y.; Han, J. D.; Bertin, N.; Chung, S.; Vidal, M.; Gerstein, M. (2004). "Annotation Transfer Between Genomes: Protein-Protein Interologs and Protein-DNA Regulogs". Genome Research. 14 (6): 1107–1118. doi:10.1101/gr.1774904. PMC 419789. PMID 15173116.
• Kemmer, D.; Huang, Y.; Shah, S. P.; Lim, J.; Brumm, J.; Yuen, M. M.; Ling, J.; Xu, T.; Wasserman, W. W.; Ouellette, B. F. (2005). "Ulysses - an application for the projection of molecular interactions across species". Genome Biology. 6 (12): R106. doi:10.1186/gb-2005-6-12-r106. PMC 1414088. PMID 16356269.
• Wiles, A. M.; Doderer, M.; Ruan, J.; Gu, T. T.; Ravi, D.; Blackman, B.; Bishop, A. J. (2010). "Building and analyzing protein interactome networks by cross-species comparisons". BMC Systems Biology. 4: 36. doi:10.1186/1752-0509-4-36. PMC 2859380. PMID 20353594.

External links

• Interactome.org Archived 2008-08-20 at the Wayback Machine: Interactome portal site.
• Interactomics.org Archived 2008-07-06 at the Wayback Machine: Interactomics portal site.
• : Cross-species interaction prediction site.