Intelectin-1

Intelectin-1, also known as omentin or intestinal lactoferrin receptor, is an intelectin encoded in humans by the ITLN1 gene.^[5][6][7] Intelectin-1 functions both as a receptor for bacterial arabinogalactans^[5] and for lactoferrin.^[8]

ITLN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WMQ, 4WMY
Identifiers
Aliases	ITLN1, HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin, intelectin 1
External IDs	OMIM: 609873; MGI: 1333831; HomoloGene: 111044; GeneCards: ITLN1; OMA:ITLN1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 160,876,540 bp[1] End 160,885,180 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 171,345,690 bp[2] End 171,362,862 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parietal pleura mucosa of ileum pericardium mucosa of sigmoid colon germinal epithelium rectum mucosa of transverse colon jejunal mucosa cardiac muscle tissue of right atrium duodenum Top expressed in crypt of lieberkuhn of small intestine Paneth cell duodenum jejunum intestinal villus ileum Ileal epithelium cervix embryo left colon More reference expression data BioGPS n/a
Gene ontology Molecular function carbohydrate binding calcium ion binding oligosaccharide binding metal ion binding identical protein binding Cellular component membrane raft anchored component of membrane brush border membrane receptor complex plasma membrane extracellular exosome membrane extracellular region Biological process positive regulation of glucose import positive regulation of protein phosphorylation response to nematode antimicrobial humoral response protein homotrimerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55600 16429 Ensembl ENSG00000179914 ENSMUSG00000038209 UniProt Q8WWA0 O88310 RefSeq (mRNA) NM_017625 NM_010584 RefSeq (protein) NP_060095 NP_034714 Location (UCSC) Chr 1: 160.88 – 160.89 Mb Chr 1: 171.35 – 171.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.^[9][10]

See also

• Intelectin

References

1. GRCh38: Ensembl release 89: ENSG00000179914 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038209 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T (June 2001). "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall". The Journal of Biological Chemistry. 276 (26): 23456–63. doi:10.1074/jbc.M103162200. PMID 11313366.
6. Lee JK, Schnee J, Pang M, Wolfert M, Baum LG, Moremen KW, Pierce M (January 2001). "Human homologs of the Xenopus oocyte cortical granule lectin XL35". Glycobiology. 11 (1): 65–73. doi:10.1093/glycob/11.1.65. PMID 11181563.
7. "Entrez Gene: ITLN1 intelectin 1 (galactofuranose binding)".
8. Suzuki YA, Shin K, Lönnerdal B (December 2001). "Molecular cloning and functional expression of a human intestinal lactoferrin receptor". Biochemistry. 40 (51): 15771–9. doi:10.1021/bi0155899. PMID 11747454.
9. Wesener DA, Wangkanont K, McBride R, Song X, Kraft MB, Hodges HL, Zarling LC, Splain RA, Smith DF, Cummings RD, Paulson JC, Forest KT, Kiessling LL (August 2015). "Recognition of microbial glycans by human intelectin-1". Nature Structural & Molecular Biology. 22 (8): 603–10. doi:10.1038/nsmb.3053. PMC 4526365. PMID 26148048.
10. Wangkanont K, Wesener DA, Vidani JA, Kiessling LL, Forest KT (March 2016). "Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition". The Journal of Biological Chemistry. 291 (11): 5596–610. doi:10.1074/jbc.M115.709212. PMC 4786701. PMID 26755729.

Further reading

• Suzuki YA, Lopez V, Lönnerdal B (November 2005). "Mammalian lactoferrin receptors: structure and function". Cellular and Molecular Life Sciences. 62 (22): 2560–75. doi:10.1007/s00018-005-5371-1. PMC 11139119. PMID 16261254. S2CID 265994535.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Chang BY, Peavy TR, Wardrip NJ, Hedrick JL (January 2004). "The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins". Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. 137 (1): 115–29. doi:10.1016/S1095-6433(03)00269-1. PMID 14720597.
• Wali A, Morin PJ, Hough CD, Lonardo F, Seya T, Carbone M, Pass HI (April 2005). "Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE)". Lung Cancer. 48 (1): 19–29. doi:10.1016/j.lungcan.2004.10.011. PMID 15777968.
• Schäffler A, Neumeier M, Herfarth H, Fürst A, Schölmerich J, Büchler C (December 2005). "Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1732 (1–3): 96–102. doi:10.1016/j.bbaexp.2005.11.005. PMID 16386808.
• Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW (June 2006). "Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action". American Journal of Physiology. Endocrinology and Metabolism. 290 (6): E1253-61. doi:10.1152/ajpendo.00572.2004. PMID 16531507.
• Schäffler A, Zeitoun M, Wobser H, Buechler C, Aslanidis C, Herfarth H (February 2007). "Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases". Cardiovascular Diabetology. 6: 3. doi:10.1186/1475-2840-6-3. PMC 1802733. PMID 17295929.
• Wurm S, Neumeier M, Weigert J, Schäffler A, Buechler C (February 2007). "Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults". Cardiovascular Diabetology. 6: 7. doi:10.1186/1475-2840-6-7. PMC 1804262. PMID 17311679.
• de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, McLenithan JC (June 2007). "Omentin plasma levels and gene expression are decreased in obesity". Diabetes. 56 (6): 1655–61. doi:10.2337/db06-1506. PMID 17329619.