Integrin alpha 5

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.^[5]

ITGA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VI3, 3VI4, 4WJK, 4WK0, 4WK2, 4WK4
Identifiers
Aliases	ITGA5, CD49e, FNRA, VLA5A, VLA-5, integrin subunit alpha 5
External IDs	OMIM: 135620; MGI: 96604; HomoloGene: 20508; GeneCards: ITGA5; OMA:ITGA5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 54,395,261 bp[1] End 54,419,266 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 58.9 cM Start 103,252,713 bp[2] End 103,275,190 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial arteries saphenous vein muscle layer of sigmoid colon Descending thoracic aorta stromal cell of endometrium ascending aorta smooth muscle tissue left uterine tube upper lobe of left lung right lung Top expressed in tail of embryo decidua ascending aorta aortic valve gastrula stroma of bone marrow yolk sac genital tubercle atrium urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function vascular endothelial growth factor receptor 2 binding virus receptor activity epidermal growth factor receptor binding metal ion binding platelet-derived growth factor receptor binding integrin binding protein binding cell adhesion molecule binding Cellular component cytoplasm integral component of membrane Golgi apparatus alphav-beta3 integrin-vitronectin complex membrane cell-cell junction ruffle plasma membrane synapse ruffle membrane cell surface integrin complex endoplasmic reticulum cytoplasmic vesicle external side of plasma membrane focal adhesion cell junction Biological process leukocyte cell-cell adhesion positive regulation of vascular endothelial growth factor receptor signaling pathway heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules endodermal cell differentiation positive regulation of cell migration heterotypic cell-cell adhesion wound healing, spreading of epidermal cells extracellular matrix organization memory cell-cell adhesion mediated by integrin positive regulation of sprouting angiogenesis cell-substrate adhesion cell adhesion angiogenesis positive regulation of peptidyl-tyrosine phosphorylation cell-substrate junction assembly integrin-mediated signaling pathway viral entry into host cell viral process negative regulation of anoikis leukocyte migration positive regulation of cell-substrate adhesion regulation of angiogenesis cell adhesion mediated by integrin female pregnancy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3678 16402 Ensembl ENSG00000161638 ENSMUSG00000000555 UniProt P08648 P11688 RefSeq (mRNA) NM_002205 NM_010577 NM_001314041 RefSeq (protein) NP_002196 NP_001300970 NP_034707 Location (UCSC) Chr 12: 54.4 – 54.42 Mb Chr 15: 103.25 – 103.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.^[6]

Interactions

ITGA5 has been shown to interact with GIPC1.^[7]

See also

• Cluster of differentiation
• Integrin

References

1. GRCh38: Ensembl release 89: ENSG00000161638 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000555 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest. 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.
6. "Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)".
7. Tani TT, Mercurio A M (Sep 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". J. Biol. Chem. 276 (39). United States: 36535–42. doi:10.1074/jbc.M105785200. ISSN 0021-9258. PMID 11479315.

Further reading

• Ruoslahti E (1996). "Integrin signaling and matrix assembly". Tumour Biol. 17 (2): 117–24. doi:10.1159/000217975. PMID 8658014.
• Coulombel L, Auffray I, Gaugler MH, Rosemblatt M (1997). "Expression and function of integrins on hematopoietic progenitor cells". Acta Haematol. 97 (1–2): 13–21. doi:10.1159/000203655. PMID 8980606.
• Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol. 8 (10): 390–6. doi:10.1016/S0962-8924(98)01344-0. PMID 9789327.
• Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". BioEssays. 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216. S2CID 23712246.

External links

• CD49e+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• ITGA5 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
• Overview of all the structural information available in the PDB for UniProt: P08648 (Human Integrin alpha-5) at the PDBe-KB.