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Chemical compound From Wikipedia, the free encyclopedia
Ibandronic acid is a bisphosphonate medication used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer.[4] It may also be used to treat hypercalcemia (elevated blood calcium levels). It is typically formulated as its sodium salt ibandronate sodium.[medical citation needed]
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Trade names | Boniva, Bonviva, Bondronat, others |
AHFS/Drugs.com | Monograph |
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Routes of administration | By mouth, intravenous |
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Bioavailability | 0.6% |
Protein binding | 90.9 to 99.5% (concentration-dependent) |
Metabolism | Nil |
Elimination half-life | 10 to 60 hours |
Excretion | Kidney |
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ECHA InfoCard | 100.214.537 |
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Formula | C9H23NO7P2 |
Molar mass | 319.231 g·mol−1 |
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It was patented in 1986 by Boehringer Mannheim and approved for medical use in 1996.[5]
Ibandronate is indicated for the treatment and prevention of osteoporosis in post-menopausal women.[6] In May 2003, the US Food and Drug Administration (FDA) approved ibandronate as a daily treatment for post-menopausal osteoporosis.[medical citation needed] The basis for this approval was a three-year, randomized, double-blind, placebo-controlled trial women with post-menopausal osteoporosis.[medical citation needed] Each participant also received daily oral doses of calcium and 400IUs [international units] of vitamin D.[medical citation needed] At the study's conclusion, both doses significantly reduced the occurrence risk of new vertebral fractures by 50–52 percent when compared to the effects of the placebo drug.[medical citation needed]
Ibandronate is efficacious for the prevention of metastasis-related bone fractures in multiple myeloma, breast cancer, and certain other cancers.[7]
In 2008, the US Food and Drug Administration (FDA) issued a communication warning of the possibility of severe and sometimes incapacitating bone, joint or muscle pain.[8] A study conducted by the American Society of Bone and Mineral Research concluded that long-term use of bisphosphonates, including Boniva, may increase the risk of a rare but serious fracture of the femur.[9] The drug also has been associated with osteonecrosis of the jaw, relatively rare but serious condition.[10]
Bisphosphonate | Relative potency |
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Etidronate | 1 |
Tiludronate | 10 |
Pamidronate | 100 |
Alendronate | 100-500 |
Ibandronate | 500-1000 |
Risedronate | 1000 |
Zoledronate | 5000 |
Ibandronic acid is sold under the brand names Boniva, Bondronat, Bonviva, Bandrone, Ibandrix, Adronil, Bondrova, Bonprove, and Fosfonat.
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