IVNS1ABP

Influenza virus NS1A-binding protein is a protein that in humans is encoded by the IVNS1ABP gene.^[5][6][7]

IVNS1ABP
Identifiers
Aliases	IVNS1ABP, FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1-BP, NS1BP, influenza virus NS1A binding protein, ARA3, IMD70
External IDs	OMIM: 609209; MGI: 2152389; HomoloGene: 31384; GeneCards: IVNS1ABP; OMA:IVNS1ABP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 185,296,388 bp[1] End 185,317,273 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 G1 Start 151,220,228 bp[2] End 151,240,173 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence tibia minor salivary glands ventricular zone Achilles tendon skin of abdomen bone marrow rectum skin of leg bone marrow cells Top expressed in epithelium of lens Paneth cell myocardium of ventricle medullary collecting duct efferent ductule olfactory epithelium cardiac muscle tissue of left ventricle primitive streak cumulus cell aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component actin cytoskeleton spliceosomal complex cytoskeleton nucleus transcription regulator complex nucleoplasm cytoplasm cytosol Biological process negative regulation of intrinsic apoptotic signaling pathway viral process transcription by RNA polymerase III RNA splicing response to virus negative regulation of protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10625 117198 Ensembl ENSG00000116679 ENSMUSG00000023150 UniProt Q9Y6Y0 Q920Q8 RefSeq (mRNA) NM_006469 NM_016389 NM_001039511 NM_001039512 NM_028582 NM_054102 NM_001359262 NM_001359263 RefSeq (protein) NP_006460 NP_001034600 NP_001034601 NP_473443 NP_001346191 NP_001346192 Location (UCSC) Chr 1: 185.3 – 185.32 Mb Chr 1: 151.22 – 151.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

In melanocytic cells IVNS1ABP gene expression may be regulated by MITF.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000116679 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023150 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wolff T, O'Neill RE, Palese P (Sep 1998). "NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells". J Virol. 72 (9): 7170–80. doi:10.1128/JVI.72.9.7170-7180.1998. PMC 109939. PMID 9696811.
6. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
7. "Entrez Gene: IVNS1ABP influenza virus NS1A binding protein".
8. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Further reading

• Perconti G, Ferro A, Amato F, et al. (2008). "The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control". Biochim. Biophys. Acta. 1773 (12): 1774–85. doi:10.1016/j.bbamcr.2007.09.002. PMID 17996313.
• Dunham EE, Stevens EA, Glover E, Bradfield CA (2006). "The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein". Mol. Pharmacol. 70 (1): 8–15. doi:10.1124/mol.106.024380. PMID 16582008. S2CID 8164208.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Harris CE, Boden RA, Astell CR (1999). "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice". J. Virol. 73 (1): 72–80. doi:10.1128/JVI.73.1.72-80.1999. PMC 103810. PMID 9847309.