Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene.[5][6][7][8][9]
Quick Facts Available structures, PDB ...
ITPR1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/c/c2/PBB_Protein_ITPR1_image.jpg/250px-PBB_Protein_ITPR1_image.jpg) |
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Identifiers |
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Aliases | ITPR1, ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29, inositol 1,4,5-trisphosphate receptor type 1 |
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External IDs | OMIM: 147265; MGI: 96623; HomoloGene: 1673; GeneCards: ITPR1; OMA:ITPR1 - orthologs |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - tail of epididymis
- Brodmann area 23
- primary visual cortex
- right coronary artery
- popliteal artery
- tibial arteries
- seminal vesicula
- right hemisphere of cerebellum
- orbitofrontal cortex
- left coronary artery
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| Top expressed in | - cerebellar vermis
- lobe of cerebellum
- olfactory tubercle
- vestibular membrane of cochlear duct
- primary motor cortex
- Epithelium of choroid plexus
- cingulate gyrus
- Region I of hippocampus proper
- superior frontal gyrus
- choroid plexus of fourth ventricle
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| More reference expression data |
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BioGPS | |
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Wikidata |
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Close
ITPR1 has been shown to interact with:
Yamada N, Makino Y, Clark RA, Pearson DW, Mattei MG, Guénet JL, Ohama E, Fujino I, Miyawaki A, Furuichi T (Sep 1994). "Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization". The Biochemical Journal. 302 (Pt 3): 781–90. doi:10.1042/bj3020781. PMC 1137299. PMID 7945203. van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB (Jun 2007). "Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans". PLOS Genetics. 3 (6): e108. doi:10.1371/journal.pgen.0030108. PMC 1892049. PMID 17590087. Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y (Jan 2008). "Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16". Journal of Medical Genetics. 45 (1): 32–5. doi:10.1136/jmg.2007.053942. PMID 17932120. S2CID 7730102. Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. Bibcode:2000Natur.404..197S. doi:10.1038/35004606. PMID 10724174. S2CID 205004996. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/s0092-8674(03)00716-5. PMID 14505576. S2CID 10552676.
- Stove V, Verhasselt B (Jan 2006). "Modelling thymic HIV-1 Nef effects". Current HIV Research. 4 (1): 57–64. doi:10.2174/157016206775197583. PMID 16454711.
- Joseph SK, Lin C, Pierson S, Thomas AP, Maranto AR (Oct 1995). "Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells". The Journal of Biological Chemistry. 270 (40): 23310–6. doi:10.1074/jbc.270.40.23310. PMID 7559486.
- Harnick DJ, Jayaraman T, Ma Y, Mulieri P, Go LO, Marks AR (Feb 1995). "The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation". The Journal of Biological Chemistry. 270 (6): 2833–40. doi:10.1074/jbc.270.6.2833. PMID 7852357.
- Wojcikiewicz RJ, Furuichi T, Nakade S, Mikoshiba K, Nahorski SR (Mar 1994). "Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation". The Journal of Biological Chemistry. 269 (11): 7963–9. doi:10.1016/S0021-9258(17)37145-4. PMID 8132516.
- Komalavilas P, Lincoln TM (Mar 1994). "Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase". The Journal of Biological Chemistry. 269 (12): 8701–7. doi:10.1016/S0021-9258(17)37024-2. PMID 8132598.
- Cameron AM, Steiner JP, Roskams AJ, Ali SM, Ronnett GV, Snyder SH (Nov 1995). "Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux". Cell. 83 (3): 463–72. doi:10.1016/0092-8674(95)90124-8. PMID 8521476. S2CID 11594556.
- Yan J, Khanna KK, Lavin MF (May 1996). "Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation". International Journal of Radiation Biology. 69 (5): 539–46. doi:10.1080/095530096145544. PMID 8648241.
- Quinton TM, Dean WL (Jul 1996). "Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets". Biochemical and Biophysical Research Communications. 224 (3): 740–6. doi:10.1006/bbrc.1996.1093. PMID 8713116.
- Cameron AM, Nucifora FC, Fung ET, Livingston DJ, Aldape RA, Ross CA, Snyder SH (Oct 1997). "FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain". The Journal of Biological Chemistry. 272 (44): 27582–8. doi:10.1074/jbc.272.44.27582. PMID 9346894.
- Deelman LE, Jonk LJ, Henning RH (Jan 1998). "The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor". Gene. 207 (2): 219–25. doi:10.1016/S0378-1119(97)00630-6. PMID 9511764. S2CID 265105806.
- Martin C, Chapman KE, Seckl JR, Ashley RH (Jul 1998). "Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum". Neuroscience. 85 (1): 205–16. doi:10.1016/S0306-4522(97)00612-X. PMID 9607712. S2CID 25634042.
- Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Oct 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459. S2CID 2851554.
- Kiselyov K, Xu X, Mozhayeva G, Kuo T, Pessah I, Mignery G, Zhu X, Birnbaumer L, Muallem S (Dec 1998). "Functional interaction between InsP3 receptors and store-operated Htrp3 channels". Nature. 396 (6710): 478–82. Bibcode:1998Natur.396..478K. doi:10.1038/24890. PMID 9853757. S2CID 4423316.
- Lin P, Yao Y, Hofmeister R, Tsien RY, Farquhar MG (Apr 1999). "Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi". The Journal of Cell Biology. 145 (2): 279–89. doi:10.1083/jcb.145.2.279. PMC 2133108. PMID 10209024.
- Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. Bibcode:2000Natur.404..197S. doi:10.1038/35004606. PMID 10724174. S2CID 205004996.
- Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
- Mayne M, Holden CP, Nath A, Geiger JD (Jun 2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". Journal of Immunology. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
- Tanimura A, Tojyo Y, Turner RJ (Sep 2000). "Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins". The Journal of Biological Chemistry. 275 (35): 27488–93. doi:10.1074/jbc.M004495200. PMID 10874040.