INPP4B

Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.^[5]

INPP4B
Identifiers
Aliases	INPP4B, inositol polyphosphate-4-phosphatase type II B
External IDs	OMIM: 607494; MGI: 2158925; HomoloGene: 20832; GeneCards: INPP4B; OMA:INPP4B - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.21 Start 142,023,160 bp[1] End 142,847,432 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C2|8 39.02 cM Start 82,069,185 bp[2] End 82,854,543 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Achilles tendon left testis right testis superficial temporal artery epithelium of colon sural nerve parietal pleura visceral pleura mucosa of paranasal sinus Top expressed in lumbar subsegment of spinal cord soleus muscle lymph node mesenteric lymph nodes intercostal muscle myocardium of ventricle thymus blood substantia nigra genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity protein binding hydrolase activity inositol-3,4-bisphosphate 4-phosphatase activity inositol-1,3,4-trisphosphate 4-phosphatase activity phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Cellular component cytosol cytoplasm Biological process phosphatidylinositol biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process inositol phosphate metabolic process signal transduction dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8821 234515 Ensembl ENSG00000109452 ENSMUSG00000037940 UniProt O15327 Q6P1Y8 RefSeq (mRNA) NM_001101669 NM_003866 NM_001331040 NM_001024617 NM_001297591 NM_001297593 NM_001297596 RefSeq (protein) NP_001095139 NP_001317969 NP_003857 NP_001019788 NP_001284520 NP_001284522 NP_001284525 Location (UCSC) Chr 4: 142.02 – 142.85 Mb Chr 8: 82.07 – 82.85 Mb PubMed search [3] [4]
Wikidata
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INPP4B encodes the inositol polyphosphate 4-phosphatase type II, a dual specificity phosphatase. INPP4B is involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate and phosphate groups from phosphotyrosines.^[6] There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.^[5]