IKZF4

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.^[5][6]

IKZF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MA7
Identifiers
Aliases	IKZF4, EOS, ZNFN1A4, IKAROS family zinc finger 4
External IDs	OMIM: 606239; MGI: 1343139; HomoloGene: 69103; GeneCards: IKZF4; OMA:IKZF4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 56,007,659 bp[1] End 56,038,435 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,466,712 bp[2] End 128,505,227 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell left adrenal gland adrenal cortex left adrenal cortex right adrenal gland inferior ganglion of vagus nerve muscle of thigh right adrenal cortex testicle gastrocnemius muscle Top expressed in Rostral migratory stream secondary oocyte zygote primary oocyte medulla of thymus female urethra trigeminal ganglion suprachiasmatic nucleus supraoptic nucleus yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity nucleic acid binding sequence-specific DNA binding DNA binding bHLH transcription factor binding protein homodimerization activity metal ion binding protein heterodimerization activity zinc ion binding protein domain specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm nuclear body protein-containing complex Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II protein homooligomerization protein heterooligomerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64375 22781 Ensembl ENSG00000123411 ENSMUSG00000002578 UniProt Q9H2S9 Q8C208 RefSeq (mRNA) NM_022465 NM_001351089 NM_001351090 NM_001351091 NM_001351092 NM_011772 NM_001358536 NM_001358537 RefSeq (protein) NP_071910 NP_001338018 NP_001338019 NP_001338020 NP_001338021 NP_035902 NP_001345465 NP_001345466 Location (UCSC) Chr 12: 56.01 – 56.04 Mb Chr 10: 128.47 – 128.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM]^[6]

Interactions

IKZF4 has been shown to interact with CTBP1^[7] and IKZF1.^[5][8]

References

1. GRCh38: Ensembl release 89: ENSG00000123411 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002578 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
6. "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)".
7. Perdomo, José; Crossley Merlin (Dec 2002). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. 269 (23). Germany: 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. ISSN 0014-2956. PMID 12444977.
8. Honma, Y; Kiyosawa H; Mori T; Oguri A; Nikaido T; Kanazawa K; Tojo M; Takeda J; Tanno Y; Yokoya S; Kawabata I; Ikeda H; Wanaka A (Mar 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. 447 (1). NETHERLANDS: 76–80. doi:10.1016/S0014-5793(99)00265-3. ISSN 0014-5793. PMID 10218586. S2CID 28898354.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Bao J, Lin H, Ouyang Y, et al. (2005). "Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos". Nat. Neurosci. 7 (11): 1250–8. doi:10.1038/nn1342. PMID 15494726. S2CID 1964177.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Perdomo J, Crossley M (2003). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. PMID 12444977.
• Koipally J, Georgopoulos K (2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Honma Y, Kiyosawa H, Mori T, et al. (1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. PMID 10218586. S2CID 28898354.