IGSF2

"CD101" redirects here. For the former Ohio radio station, see WWCD.

Immunoglobulin superfamily, member 2 (IGSF2) also known as CD101 (Cluster of Differentiation 101), is a human gene.^[5]

CD101
Identifiers
Aliases	CD101, EWI-101, IGSF2, V7, CD101 molecule
External IDs	OMIM: 604516; MGI: 2685862; HomoloGene: 3142; GeneCards: CD101; OMA:CD101 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.1 Start 117,001,750 bp[1] End 117,036,552 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 100,900,845 bp[2] End 100,936,872 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte testicle right lung mucosa of transverse colon bone marrow cells ventricular zone upper lobe of left lung blood rectum Top expressed in granulocyte morula jejunum duodenum muscle of thigh bone marrow ileum lung colon thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Cellular component plasma membrane extracellular exosome membrane integral component of membrane Biological process cell surface receptor signaling pathway positive regulation of myeloid leukocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9398 630146 Ensembl ENSG00000134256 ENSMUSG00000086564 UniProt Q93033 A8E0Y8 RefSeq (mRNA) NM_001256106 NM_001256109 NM_001256111 NM_004258 NM_001099332 NM_001167906 RefSeq (protein) NP_001243035 NP_001243038 NP_001243040 NP_004249 NP_001161378 Location (UCSC) Chr 1: 117 – 117.04 Mb Chr 3: 100.9 – 100.94 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000134256 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000086564 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IGSF2 immunoglobulin superfamily, member 2".

Further reading

• Rivas A, Ruegg CL, Zeitung J, et al. (1995). "V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies". J. Immunol. 154 (9): 4423–33. doi:10.4049/jimmunol.154.9.4423. PMID 7722299.
• Ruegg CL, Rivas A, Madani ND, et al. (1995). "V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene". J. Immunol. 154 (9): 4434–43. doi:10.4049/jimmunol.154.9.4434. PMID 7722300. S2CID 22225700.
• Soares LR, Rivas A, Tsavaler L, Engleman EG (1997). "Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism". J. Immunol. 159 (3): 1115–24. doi:10.4049/jimmunol.159.3.1115. PMID 9233604. S2CID 32846335.
• Bagot M, Martinel I, Charue D, et al. (1998). "CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation". Tissue Antigens. 50 (5): 439–48. doi:10.1111/j.1399-0039.1997.tb02898.x. PMID 9389317.
• Soares LR, Tsavaler L, Rivas A, Engleman EG (1998). "V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation". J. Immunol. 161 (1): 209–17. doi:10.4049/jimmunol.161.1.209. PMID 9647226. S2CID 24815632.
• Bouloc A, Boulland ML, Geissmann F, et al. (2000). "CD101 expression by Langerhans cell histiocytosis cells". Histopathology. 36 (3): 229–32. doi:10.1046/j.1365-2559.2000.00827.x. PMID 10692025. S2CID 36983914.
• Bouloc A, Bagot M, Delaire S, et al. (2001). "Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production". Eur. J. Immunol. 30 (11): 3132–9. doi:10.1002/1521-4141(200011)30:11<3132::AID-IMMU3132>3.0.CO;2-E. PMID 11093127. S2CID 45350340.
• Stipp CS, Kolesnikova TV, Hemler ME (2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J. Biol. Chem. 276 (44): 40545–54. doi:10.1074/jbc.M107338200. PMID 11504738.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Meyer N, Petrella T, Poszepczynska-Guigne E, et al. (2005). "CD4+ CD56+ blastic tumor cells express CD101 molecules". J. Invest. Dermatol. 124 (3): 668–9. doi:10.1111/j.0022-202X.2005.23617.x. PMID 15737213.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• IGSF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)