IFNA7

Interferon alpha-7 is a protein that in humans is encoded by the IFNA7 gene.^[5][6]

IFNA7
Identifiers
Aliases	IFNA7, IFN-alphaJ, IFNA-J, interferon, alpha 7, interferon alpha 7
External IDs	OMIM: 147567; MGI: 2667155; HomoloGene: 113762; GeneCards: IFNA7; OMA:IFNA7 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.3 Start 21,201,469 bp[1] End 21,202,205 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C4|4 42.02 cM Start 88,561,878 bp[2] End 88,562,696 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell tibialis anterior muscle mucosa of ileum skin of thigh sural nerve Top expressed in embryo embryo More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process defense response adaptive immune response response to exogenous dsRNA cell-cell signaling response to virus blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein natural killer cell activation involved in immune response B cell proliferation humoral immune response defense response to virus type I interferon signaling pathway B cell differentiation T cell activation involved in immune response cytokine-mediated signaling pathway innate immune response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3444 230396 Ensembl ENSG00000214042 ENSMUSG00000063376 UniProt P01567 Q80SU4 RefSeq (mRNA) NM_021057 NM_177347 RefSeq (protein) NP_066401 NP_796321 Location (UCSC) Chr 9: 21.2 – 21.2 Mb Chr 4: 88.56 – 88.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000214042 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
6. "Entrez Gene: IFNA7 interferon, alpha 7".

Further reading

• Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology. 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.
• Capobianchi MR, Ankel H, Ameglio F, et al. (1992). "Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer". AIDS Res. Hum. Retroviruses. 8 (5): 575–9. doi:10.1089/aid.1992.8.575. PMID 1381203.
• Tyring SK, Cauda R, Tumbarello M, et al. (1991). "Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin-1 and tumor necrosis factor but depress production of interferon-alpha, interferon-gamma and interleukin-2". Viral Immunol. 4 (1): 33–42. doi:10.1089/vim.1991.4.33. PMID 1905933.
• Stine KC, Bolognesi D, Weinhold KJ (1989). "Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity". Journal of Biological Response Modifiers. 8 (5): 501–10. PMID 2552026.
• Cohen S, Velan B, Grosfeld H, et al. (1985). "Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells". Dev. Biol. Stand. 60: 111–22. PMID 2995168.
• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
• Ullrich A, Gray A, Goeddel DV, Dull TJ (1982). "Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster". J. Mol. Biol. 156 (3): 467–86. doi:10.1016/0022-2836(82)90261-3. PMID 6181262.
• Ameglio F, Capobianchi MR, Castilletti C, et al. (1994). "Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells; correlation with the induction of other cytokines". Clin. Exp. Immunol. 95 (3): 455–8. doi:10.1111/j.1365-2249.1994.tb07018.x. PMC 1535081. PMID 7511078.
• Ankel H, Capobianchi MR, Castilletti C, Dianzani F (1994). "Interferon induction by HIV glycoprotein 120: role of the V3 loop". Virology. 205 (1): 34–43. doi:10.1006/viro.1994.1617. PMID 7526537.
• Nair MP, Chadha KC, Stadler I, et al. (1995). "Differential effects of human immunodeficiency virus type 1 envelope protein gp120 on interferon production by mononuclear cells from adults and neonates". Clin. Diagn. Lab. Immunol. 2 (4): 434–8. doi:10.1128/CDLI.2.4.434-438.1995. PMC 170174. PMID 7583919.
• Borghi P, Fantuzzi L, Varano B, et al. (1995). "Induction of interleukin-10 by human immunodeficiency virus type 1 and its gp120 protein in human monocytes/macrophages". J. Virol. 69 (2): 1284–7. doi:10.1128/JVI.69.2.1284-1287.1995. PMC 188705. PMID 7815507.
• Capobianchi MR, Ameglio F, Cordiali Fei P, et al. (1994). "Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120". AIDS Res. Hum. Retroviruses. 9 (10): 957–62. doi:10.1089/aid.1993.9.957. PMID 7904170.
• Chen YH, Böck G, Vornhagen R, et al. (1994). "HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells". Int. Arch. Allergy Immunol. 104 (3): 227–31. doi:10.1159/000236670. PMID 7913356.
• Francis ML, Meltzer MS (1993). "Induction of IFN-alpha by HIV-1 in monocyte-enriched PBMC requires gp120-CD4 interaction but not virus replication". J. Immunol. 151 (4): 2208–16. doi:10.4049/jimmunol.151.4.2208. PMID 8345204.
• Shirazi Y, Pitha PM (1993). "Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells". Virology. 193 (1): 303–12. doi:10.1006/viro.1993.1126. PMID 8438572.
• Ankel H, Capobianchi MR, Frezza F, et al. (1996). "Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids". Virology. 221 (1): 113–9. doi:10.1006/viro.1996.0357. PMID 8661419.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
• Schols D, De Clercq E (1996). "Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production". J. Virol. 70 (8): 4953–60. doi:10.1128/JVI.70.8.4953-4960.1996. PMC 190447. PMID 8764000.
• Hussain M, Gill DS, Liao MJ (1997). "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population". J. Interferon Cytokine Res. 16 (10): 853–9. doi:10.1089/jir.1996.16.853. PMID 8910771.