IFNA13

Interferon alpha-1/13, also known as IFN-alpha-1/13, is a protein that in humans is encoded by the IFNA1 and IFNA13 genes.^[3][4]

IFNA13
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3UX9
Identifiers
Aliases	IFNA13, interferon alpha 13
External IDs	OMIM: 147578; HomoloGene: 136811; GeneCards: IFNA13; OMA:IFNA13 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.3 Start 21,367,424 bp[1] End 21,368,962 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum putamen primary visual cortex caudate nucleus Brodmann area 9 amygdala hippocampus proper gastric mucosa stromal cell of endometrium substantia nigra n/a More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response cytokine-mediated signaling pathway innate immune response regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3447 n/a Ensembl ENSG00000233816 n/a UniProt P01562 n/a RefSeq (mRNA) NM_006900 n/a RefSeq (protein) NP_076918 n/a Location (UCSC) Chr 9: 21.37 – 21.37 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000233816 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: interferon".
4. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (October 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.

Further reading

• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
• Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
• Weber H, Weissmann C (1983). "Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli". Nucleic Acids Res. 11 (16): 5661–9. doi:10.1093/nar/11.16.5661. PMC 326304. PMID 6310510.
• Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G (2007). "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes". Genomics. 89 (3): 307–15. doi:10.1016/j.ygeno.2006.11.012. PMC 4647941. PMID 17207965.
• Goeddel DV, Leung DW, Dull TJ, Gross M, Lawn RM, McCandliss R, Seeburg PH, Ullrich A, Yelverton E (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. Bibcode:1981Natur.290...20G. doi:10.1038/290020a0. PMID 6163083. S2CID 1900300.
• Myers MP, Andersen JN, Cheng A, Tremblay ML, Horvath CM, Parisien JP, Salmeen A, Barford D, Tonks NK (2001). "TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B". J. Biol. Chem. 276 (51): 47771–4. doi:10.1074/jbc.C100583200. PMID 11694501.
• Hussain M, Ni D, Gill D, Liao MJ (2000). "IFN-alpha1a gene is the major variant in the North American population". J. Interferon Cytokine Res. 20 (9): 763–8. doi:10.1089/10799900050151021. PMID 11032395.
• Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R (2009). "Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes". Pediatr. Infect. Dis. J. 28 (4): 333–5. doi:10.1097/INF.0b013e31818e2aa9. PMID 19258923. S2CID 25601837.
• Hardy MP, Owczarek CM, Jermiin LS, Ejdebäck M, Hertzog PJ (2004). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.
• Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7. doi:10.1038/ejhg.2010.98. PMC 2950898. PMID 20588308.
• Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, Slot Rv, Wijmenga C, Goeman JJ (2007). "Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes". J. Infect. Dis. 196 (6): 826–34. doi:10.1086/520886. PMID 17703412.
• Shuai K, Horvath CM, Huang LH, Qureshi SA, Cowburn D, Darnell Jr JE (1994). "Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions". Cell. 76 (5): 821–8. doi:10.1016/0092-8674(94)90357-3. PMID 7510216. S2CID 41612814.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sen GC, Lengyel P (1992). "The interferon system. A bird's eye view of its biochemistry". J. Biol. Chem. 267 (8): 5017–20. doi:10.1016/S0021-9258(18)42719-6. PMID 1371992.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tiefenbrun N, Melamed D, Levy N, Resnitzky D, Hoffman I, Reed SI, Kimchi A (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
• Nagata S, Mantei N, Weissmann C (1980). "The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha". Nature. 287 (5781): 401–8. Bibcode:1980Natur.287..401N. doi:10.1038/287401a0. PMID 6159536. S2CID 29500779.
• Todokoro K, Kioussis D, Weissmann C (1984). "Two non-allelic human interferon alpha genes with identical coding regions". EMBO J. 3 (8): 1809–12. doi:10.1002/j.1460-2075.1984.tb02050.x. PMC 557600. PMID 6479148.
• Schuurhof A, Bont L, Siezen CL, Hodemaekers H, Van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". Pediatr. Pulmonol. 45 (6): 608–13. doi:10.1002/ppul.21229. PMID 20503287. S2CID 24678182.

IFNA13 is an interferon gene.