IER3

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene.^[5][6]

IER3
Identifiers
Aliases	IER3, DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1, immediate early response 3
External IDs	OMIM: 602996; MGI: 104814; HomoloGene: 2894; GeneCards: IER3; OMA:IER3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 30,743,199 bp[1] End 30,744,548 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 36,132,576 bp[2] End 36,133,815 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa islet of Langerhans gastric mucosa gallbladder body of stomach granulocyte bone marrow left uterine tube vagina right auricle Top expressed in right lung lobe granulocyte decidua stroma of bone marrow cervix motor neuron endothelial cell of lymphatic vessel left lung corneal stroma superior surface of tongue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane membrane nucleus cytosol Biological process anatomical structure morphogenesis regulation of response to DNA damage stimulus negative regulation of apoptotic process apoptotic process regulation of phosphatidylinositol 3-kinase signaling regulation of cell death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8870 15937 Ensembl ENSG00000137331 ENSMUSG00000003541 UniProt P46695 P46694 Q91VZ5 RefSeq (mRNA) NM_052815 NM_003897 NM_133662 RefSeq (protein) NP_003888 NP_598423 Location (UCSC) Chr 6: 30.74 – 30.74 Mb Chr 17: 36.13 – 36.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000137331 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003541 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kondratyev AD, Chung KN, Jung MO (May 1996). "Identification and characterization of a radiation-inducible glycosylated human early-response gene". Cancer Res. 56 (7): 1498–502. PMID 8603392.
6. Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF (Aug 1998). "IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival". Science. 281 (5379): 998–1001. Bibcode:1998Sci...281..998W. doi:10.1126/science.281.5379.998. PMID 9703517.
7. "Entrez Gene: IER3 immediate early response 3".

Further reading

• Wu MX (2003). "Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis". Apoptosis. 8 (1): 11–8. doi:10.1023/A:1021688600370. PMID 12510147. S2CID 20935065.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Schäfer H, Trauzold A, Siegel EG, et al. (1996). "PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line". Cancer Res. 56 (11): 2641–8. PMID 8653710.
• Pietzsch A, Büchler C, Aslanidis C, Schmitz G (1997). "Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine". Biochem. Biophys. Res. Commun. 235 (1): 4–9. doi:10.1006/bbrc.1997.6715. PMID 9196025.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Pietzsch A, Büchler C, Schmitz G (1998). "Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene". Biochem. Biophys. Res. Commun. 245 (3): 651–7. doi:10.1006/bbrc.1998.8500. PMID 9588170.
• Schäfer H, Diebel J, Arlt A, et al. (1998). "The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB". FEBS Lett. 436 (2): 139–43. doi:10.1016/S0014-5793(98)01109-0. PMID 9781666. S2CID 28479652.
• Kobayashi T, Pittelkow MR, Warner GM, et al. (1998). "Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3". Biochem. Biophys. Res. Commun. 251 (3): 868–73. doi:10.1006/bbrc.1998.9556. PMID 9791001.
• Kumar R, Kobayashi T, Warner GM, et al. (1999). "A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes". Biochem. Biophys. Res. Commun. 253 (2): 336–41. doi:10.1006/bbrc.1998.9692. PMID 9878538.
• Schäfer H, Arlt A, Trauzold A, et al. (1999). "The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo". Biochem. Biophys. Res. Commun. 262 (1): 139–45. doi:10.1006/bbrc.1999.1131. PMID 10448082.
• Feldmann KA, Pittelkow MR, Roche PC, et al. (2001). "Expression of an immediate early gene, IEX-1, in human tissues". Histochem. Cell Biol. 115 (6): 489–97. doi:10.1007/s004180100284. PMID 11455449. S2CID 24380294.
• Zhang Y, Schlossman SF, Edwards RA, et al. (2002). "Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice". Proc. Natl. Acad. Sci. U.S.A. 99 (2): 878–83. Bibcode:2002PNAS...99..878Z. doi:10.1073/pnas.022326699. PMC 117399. PMID 11782530.
• Im HJ, Pittelkow MR, Kumar R (2002). "Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1". J. Biol. Chem. 277 (17): 14612–21. doi:10.1074/jbc.M109414200. PMC 2895739. PMID 11844788.
• Ohki R, Yamamoto K, Mano H, et al. (2002). "Identification of mechanically induced genes in human monocytic cells by DNA microarrays". J. Hypertens. 20 (4): 685–91. doi:10.1097/00004872-200204000-00026. PMID 11910304. S2CID 34968458.
• Im HJ, Craig TA, Pittelkow MR, Kumar R (2002). "Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression". Oncogene. 21 (23): 3706–14. doi:10.1038/sj.onc.1205450. PMID 12032839. S2CID 38132204.
• Garcia J, Ye Y, Arranz V, et al. (2002). "IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation". EMBO J. 21 (19): 5151–63. doi:10.1093/emboj/cdf488. PMC 129026. PMID 12356731.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.