ICK (gene)

Serine/threonine-protein kinase, Intestinal cell kinase or ICK^[5] is an enzyme that in humans is encoded by the ICK gene.^[6][7]

CILK1
Identifiers
Aliases	CILK1, ECO, LCK2, MRK, intestinal cell (MAK-like) kinase, intestinal cell kinase, EJM10, ICK, ciliogenesis associated kinase 1, hICK
External IDs	OMIM: 612325; MGI: 1934157; HomoloGene: 69218; GeneCards: CILK1; OMA:CILK1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p12.1 Start 53,001,279 bp[1] End 53,061,824 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E1 Start 78,016,474 bp[2] End 78,079,389 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva left adrenal gland left adrenal cortex right adrenal cortex ganglionic eminence olfactory zone of nasal mucosa rectum placenta Achilles tendon C1 segment Top expressed in trigeminal ganglion Rostral migratory stream epithelium of stomach Paneth cell gastrula external carotid artery genital tubercle ciliary body substantia nigra zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity metal ion binding kinase activity protein serine/threonine kinase activity protein binding ATP binding magnesium ion binding Cellular component ciliary basal body cytosol cell projection ciliary tip cytoskeleton cilium ciliary base nucleus cytoplasm fibrillar center Biological process intracellular signal transduction phosphorylation multicellular organism development protein phosphorylation cell projection organization signal transduction intraciliary anterograde transport intraciliary retrograde transport cilium assembly regulation of gene expression intraciliary transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22858 56542 Ensembl ENSG00000112144 ENSMUSG00000009828 UniProt Q9UPZ9 Q9JKV2 RefSeq (mRNA) NM_014920 NM_016513 NM_001375397 NM_001375398 NM_001375399 NM_001375400 NM_001375401 NM_001375402 NM_173041 NM_001163780 NM_019987 RefSeq (protein) NP_055735 NP_057597 NP_001362326 NP_001362327 NP_001362328 NP_001362329 NP_001362330 NP_001362331 NP_001157252 NP_064371 Location (UCSC) Chr 6: 53 – 53.06 Mb Chr 9: 78.02 – 78.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000112144 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009828 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "ICK intestinal cell kinase [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-01-26.
6. Yang T, Jiang Y, Chen J (Jul 2002). "The identification and subcellular localization of human MRK". Biomol Eng. 19 (1): 1–4. doi:10.1016/S1389-0344(02)00002-3. PMID 12103360.
7. "Entrez Gene: ICK intestinal cell (MAK-like) kinase".

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Togawa K, Yan YX, Inomoto T, et al. (2000). "Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases". J. Cell. Physiol. 183 (1): 129–39. doi:10.1002/(SICI)1097-4652(200004)183:1<129::AID-JCP15>3.0.CO;2-S. PMID 10699974. S2CID 41279862.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fu Z, Schroeder MJ, Shabanowitz J, et al. (2005). "Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase". Mol. Cell. Biol. 25 (14): 6047–64. doi:10.1128/MCB.25.14.6047-6064.2005. PMC 1168834. PMID 15988018.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.