IC-26
Chemical compound From Wikipedia, the free encyclopedia
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Chemical compound From Wikipedia, the free encyclopedia
IC-26[1] (WIN 1161-3, Methiodone)[2] is an analogue of the opioid analgesic methadone, where the carbonyl group has been replaced by the bioisosteric sulfone group.
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Formula | C20H27NO2S |
Molar mass | 345.50 g·mol−1 |
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Human and animal studies suggest that IC-26 is around the same potency as methadone,[3][4] although other studies have found its activity to be inconsistent between different patients, with consistent opioid activity only being seen at a dose several times that of methadone. IC-26 was assessed for its abuse potential, but despite being found to have similar potential to morphine for development of dependence[5] it was never placed under international control as an illegal drug.
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