IC-26

For other uses, see IC 26 (disambiguation).

IC-26^[1] (WIN 1161-3, Methiodone)^[2] is an analogue of the opioid analgesic methadone, where the carbonyl group has been replaced by the bioisosteric sulfone group.

IC-26

Identifiers
IUPAC name 4-ethylsulfonyl-N,N-dimethyl-4,4-diphenylbutan-2-amine
CAS Number	114538-73-7 Y 60662-79-5 (hydrochloride)
PubChem CID	113832
ChemSpider	102014
UNII	ZSY3T8J4AQ
CompTox Dashboard (EPA)	DTXSID401018280
Chemical and physical data
Formula	C20H27NO2S
Molar mass	345.50 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCS(=O)(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
InChI InChI=1S/C20H27NO2S/c1-5-24(22,23)20(16-17(2)21(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3 Key:NLPGJSPLDNDKKZ-UHFFFAOYSA-N
(verify)

Human and animal studies suggest that IC-26 is around the same potency as methadone,^[3][4] although other studies have found its activity to be inconsistent between different patients, with consistent opioid activity only being seen at a dose several times that of methadone. IC-26 was assessed for its abuse potential, but despite being found to have similar potential to morphine for development of dependence^[5] it was never placed under international control as an illegal drug.

See also

• Dextromoramide
• Dipipanone
• MT-45
• Phenadoxone