Hyperprothrombinemia

Hyperprothrombinemia is a state of high of prothrombin levels in the blood^[1] which leads to hypercoagulability. An example of a genetic cause includes the mutation prothrombin G20210A.^[2] Hyperprothrombinemia is a risk factor for venous thromboembolism.^[2]

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[1]
Hyperprothrombinemia Merriam Webster Dictionary. Accessed January 19, 2012.
[2]
Tripodi A (2002). "Laboratory diagnosis of thrombophilic states: where do we stand?". Pathophysiol Haemost Thromb. 32 (5–6): 245–8. doi:10.1159/000073574. PMID 13679650.

Colucci, Mario; Binetti, Bianca M.; Tripodi, Armando; Chantarangkul, Veena; Semeraro, Nicola (March 15, 2004). "Hyperprothrombinemia associated with prothrombin G20210A mutation inhibits plasma fibrinolysis through a TAFI-mediated mechanism". Blood. 103 (6). American Society of Hematology: 2157–2161. doi:10.1182/blood-2003-06-2169. ISSN 0006-4971. PMID 14630828.
CASTOLDI, E.; SIMIONI, P.; TORMENE, D.; THOMASSEN, M.C.L.G.D.; SPIEZIA, L.; GAVASSO, S.; ROSING, J. (2007). "Differential effects of high prothrombin levels on thrombin generation depending on the cause of the hyperprothrombinemia". Journal of Thrombosis and Haemostasis. 5 (5). Elsevier BV: 971–979. doi:10.1111/j.1538-7836.2007.02448.x. ISSN 1538-7836. PMID 17461930.

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