Hydrocortisone sodium succinate

Hydrocortisone sodium succinate, sold under the brand name Solu-Cortef among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester.^[3]

Hydrocortisone sodium succinate

Clinical data
Trade names	Solu-Cortef
AHFS/Drugs.com	Monograph
License data	US DailyMed: Hydrocortisone sodium succinate
Routes of administration	Intravenous, intramuscular
Drug class	Corticosteroid; Glucocorticoid
ATC code	A01AC03 (WHO)
Legal status
Legal status	AU: S4 (Prescription only)[1] US: ℞-only[2]
Identifiers
IUPAC name Sodium 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate
CAS Number	125-04-2
PubChem CID	23694214
DrugBank	DBSALT001297
ChemSpider	390144
UNII	50LQB69S1Z
KEGG	D00978
ChEBI	CHEBI:5782
ChEMBL	ChEMBL1200495
CompTox Dashboard (EPA)	DTXSID2049006
ECHA InfoCard	100.004.296
Chemical and physical data
Formula	C25H34NaO8
Molar mass	485.529 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
InChI InChI=1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30);/q;+1/p-1/t16-,17-,18-,22+,23-,24-,25-;/m0./s1 Key:HHZQLQREDATOBM-CODXZCKSSA-M

Hydrocortisone sodium succinate was approved for medical use in the United States in 1955.^[2]

References

1. "CIPLA HYDROCORTISONE, CORTI-H, CORTICIP, HYDROCIP (Cipla Australia Pty Ltd)". Department of Health and Aged Care. Archived from the original on 18 March 2023.
2. "Solu-Cortef- hydrocortisone sodium succinate injection, powder, for solution". DailyMed. 19 August 2021. Retrieved 23 December 2023.
3. Brownell CL, Priff N (2009). "Hydrocortisone". Nursing2009 Student Drug Handbook (10th ed.). Philadelphia: Wolters Kluwer. p. 642. ISBN 978-0-7817-8883-0.