Homing (hematopoietic)

Homing is the phenomenon whereby cells migrate to the organ of their origin. By homing, transplanted hematopoietic cells are able to travel to and engraft (establish residence) in the bone marrow. Various chemokines^[1] and receptors^[2] are involved in the homing of hematopoietic stem cells.^[3]

Sites

• Bone marrow
• Lymph nodes^[4]
• Skin

References

1. Cyster, JG; Ngo, VN; Ekland, EH; Gunn, MD; Sedgwick, JD; Ansel, KM (1999). Chemokines and B-cell homing to follicles. Current Topics in Microbiology and Immunology. Vol. 246. pp. 87–92, discussion 93. doi:10.1007/978-3-642-60162-0_11. ISBN 978-3-642-64283-8. PMID 10396043.
2. Lopez-Giral, S.; Quintana, NE; Cabrerizo, M; Alfonso-Pérez, M; Sala-Valdés, M; De Soria, VG; Fernández-Rañada, JM; Fernández-Ruiz, E; Muñoz, C (23 April 2004). "Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination". Journal of Leukocyte Biology. 76 (2): 462–471. doi:10.1189/jlb.1203652. PMID 15155773.
3. Yusuf, Rushdia Z.; Scadden, David T. (17 March 2009). "Homing of Hematopoietic Cells to the Bone Marrow". Journal of Visualized Experiments (25): e1104. doi:10.3791/1104. PMC 2762899. PMID 19295497. Retrieved 23 December 2012.
4. von Andrian, Ulrich H.; Mempel, Thorsten R. (1 November 2003). "Homing and cellular traffic in lymph nodes" (PDF). Nature Reviews Immunology. 3 (11): 867–878. doi:10.1038/nri1222. PMID 14668803. S2CID 5199142. Archived from the original (PDF) on 29 July 2010. Retrieved 23 December 2012.