Herbert Kuhl

Herbert Kuhl is a German gynecologist who has published extensively in the areas of estrogens, progestogens, menopause, hormonal contraception, and menopausal hormone therapy.^[1] His works include numerous original and review articles and several books.^[1] Kuhl is a member of many medical societies and has received various scientific awards.^[1]

Herbert Kuhl
A photo of Kuhl taken from a 1999 paper[1]
Born	1940 (age 83–84) Aschaffenburg, Germany
Nationality	German
Education	Goethe University Frankfurt: chemistry and biochemistry (1961–1967); doctorate in biochemistry and pharmacy (1972); postdoctoral qualification in human medicine for the subject of experimental endocrinology (1977)[1]
Occupation(s)	Gynecologist; Medical researcher
Years active	1970[2]–present
Medical career
Profession	Professor, physician
Institutions	Department of Obstetrics and Gynecology, J. W. Goethe University of Frankfurt; Universitäts-Frauenklinik in Frankfurt
Research	Gynecology

Among Kuhl's most widely cited publications is his 2005 literature review in the journal Climacteric, Pharmacology of Estrogens and Progestogens: Influence of Different Routes of Administration.^[3][4] He has published several articles interpreting the findings of the Women's Health Initiative (WHI) study.^{[5][6][7][8][9][10][11]}

Kuhl was born in Aschaffenburg, Germany in 1940.^[1] He was educated at the Goethe University Frankfurt from 1961 to 1977.^[1] Kuhl first published in 1970.^[2] From 1981, he was a professor at the Universitäts-Frauenklinik (University Women's Clinic) of the Goethe University Frankfurt.^[5] Until 2013, Kuhl continued to be affiliated with this institution.^[11] Since then however, he has listed no affiliation in his publications except that he resides in Aschaffenburg, Germany.^[12][13]

Selected publications

Books

Authored books

• Kuhl, Herbert; Taubert, Hans-Dieter (1987). Das Klimakterium – Pathophysiologie, Klinik, Therapie [The Climacteric – Pathophysiology, Clinic, Therapy] (in German). Stuttgart, Germany: Thieme Verlag. ISBN 978-3137008019. OCLC 19780387. OL 31949169M. (1st and only edition)
• Hans-Dieter Taubert; Herbert Kuhl (1995). Kontrazeption mit Hormonen: ein Leitfaden für die Praxis [Hormonal Contraception: A Practical Guide] (in German) (2 ed.). Stuttgart, Germany: Thieme. ISBN 978-3-13-608802-9. OCLC 1068026728. (1st edition published in 1981)
• Herbert Kuhl; Claudia Jung-Hoffman (1999). Kontrazeption [Contraception] (in German) (2 ed.). Georg Thieme Verlag. ISBN 978-3131179920. OCLC 237359985. OL 12671120M. (1st edition published in 1996)
• Kuhl, Herbert; Wiegratz, Inka (1 January 2008). Klimakterium, Postmenopause und Hormonsubstitution [Climacteric, Postmenopause and Hormone Replacement] (in German) (4 ed.). UNI-MED-Verlag. ISBN 978-3-83742-043-2. OCLC 553736917. OL 31949179M. (Earlier editions published in 1999 (1st), 2001 (2nd), and 2005/2006 (3rd))
• Inka Wiegratz; Herbert Kuhl (2010). Langzyklus [Long Cycle] (in German). Georg Thieme Verlag. ISBN 978-3-13-153301-2. OCLC 649505497. (1st and only edition)

Edited books

• Taubert, Hans-Dieter; Kuhl, Herbert, eds. (1984). The Inadequate Luteal Phase: Pathophysiology, Diagnostics, Therapy [The Proceedings of the 7th Freiburg Colloquium, a Serono Workshop on Reproductive Medicine Held at Frieburg/Breisgau, September 1983]. Lancaster/Boston: MTP Press Limited. ISBN 978-94-015-7164-7. OCLC 60090529.
• Kuhl, Herbert, ed. (December 1990), "Pharmacokinetics of Oral Contraceptive Steroids and Drug Interaction: Salzburg, Austria, September 14-16, 1989", American Journal of Obstetrics and Gynecology, 163 (6 Part 2), St. Louis: Mosby-Year Book: 2113–2218, eISSN 1097-6868, ISSN 0002-9378, OCLC 83180966, OL 33197830M, PMID 1979469
• Kuhl, H.; Nikolov, R., eds. (1998). Re-evaluation of Contraceptive Steroids [XV FIGO World Congress of Gynaecology and Obstetrics, Copenhagen, Denmark, August 1997]. Bad Blankenburg: Harfe Verlag/Jenapharm. OCLC 722431314.
• Kuhl, Herbert; Braendle, Wilhelm; Breckwoldt, Meinert; Riecher-Rössler, Anita; Rohde, Anke (2002). Sexualhormone und Psyche: Grundlagen, Symptomatik, Erkrankungen, Therapie [Sex Hormones and Psyche: Fundamentals, Symptoms, Diseases, Therapy] (in German). Georg Thieme Verlag. doi:10.1055/b-002-19463. ISBN 9783131326218. OCLC 838442034.
• Braendle, W.; Dören, M.; Heitmann, C.; Kleinkauf-Houcken, A.; Kruse, H.-P.; Kuhl, H. (2005). Das Klimakterium: Endokrinologie, Pharmakologie der Hormone und Hormonsubstitution [The Climacteric: Endocrinology, Pharmacology of Hormones, and Hormone Substitution]. Edition Gynäkologie und Geburtsmedizin (in German). Vol. 12 (2 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. ISBN 978-3-8047-2063-3. ISSN 0945-0475. OCLC 254206136. (1st edition published in 2000)

Book chapters

• Kuhl, H (1998). "Adverse effects of estrogen treatment: natural vs. synthetic estrogens". In Lippert, T. H.; Mueck, A. O.; Ginsburg, J. (eds.). Sex Steroids and the Cardiovascular System: The Proceedings of the 1st Interdisciplinary Workshop, Tuebingen, Germany, October 1996. London/New York: Parthenon. pp. 201–210. ISBN 9781850709565.
• Kuhl, H. (1999). "Hormonal Contraception". In Oettel, M.; Schillinger, E. (eds.). Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogens. Handbook of Experimental Pharmacology. Vol. 135 / 2. Berlin/Heidelberg: Springer. pp. 363–407. doi:10.1007/978-3-642-60107-1_18. eISSN 1865-0325. ISBN 978-3-642-64261-6. ISSN 0171-2004.
• Kuhl, H (2001). "Pharmacology of Estrogens and Gestagens" (PDF). In Franz H. Fischl (ed.). Menopause - Andropause: Hormone Replacement Therapy Through the Ages (1 ed.). Gablitz: Gablitz Krause und Pachernegg. pp. 33–50. ISBN 978-3-901299-34-6. OCLC 181435602.

Journal articles

Reviews

• Kuhl H (December 1986). "Hormonsubstitution durch Injektionspräparate und Hautimplantate" [Hormone substitution by injectable preparations and skin implants]. Der Gynäkologe (in German). 19 (4): 241–247. PMID 3817596.
• Kuhl, H. (September 1990). "Pharmacokinetics of oestrogens and progestogens". Maturitas. 12 (3): 171–197. doi:10.1016/0378-5122(90)90003-O. ISSN 0378-5122. PMID 2170822.
• Kuhl, H. (December 1990). "Ovulationshemmer: Die Bedeutung der Östrogendosis" [Ovulation Preventives: The Significance of the Estrogen Dose]. Geburtshilfe und Frauenheilkunde (in German). 50 (12): 910–922. doi:10.1055/s-2008-1026392. eISSN 1438-8804. ISSN 0016-5751. PMID 2086334.
• Kuhl, Herbert (February 1996). "Comparative Pharmacology of Newer Progestogens". Drugs. 51 (2): 188–215. doi:10.2165/00003495-199651020-00002. ISSN 0012-6667. PMID 8808163. S2CID 1019532.
• Kuhl, Herbert (May 1996). "Effects of progestogens on haemostasis". Maturitas. 24 (1–2): 1–19. doi:10.1016/0378-5122(96)00994-2. ISSN 0378-5122. PMID 8794429.
• Kuhl, H. (18 April 1997). "Metabolische Effekte der Östrogene und Gestagene" [Metabolic effects of estrogens and progestogens]. Der Gynäkologe (in German). 30 (4): 357–369. doi:10.1007/PL00003042. ISSN 0017-5994. S2CID 43381309.
• Kuhl, H. (1998). "Pharmakologie von Sexualsteroiden" [Pharmacology of sex hormones]. Der Gynäkologe (in German). 31 (10): 832–847. doi:10.1007/s001290050341. ISSN 0017-5994. S2CID 20941492.
• Kuhl H (2000). "Pharmacology of estradiol and estriol". Menopause Review. 5. Société Européenne de Ménopause: 23–44. ISSN 1272-9868. OCLC 473540298.
• Kuhl H (2001). "Pharmacology of Progestogens. Basic aspects - progesterone derivatives". Menopause Review. 6 (1). Société Européenne de Ménopause: 9–16. ISSN 1272-9868. OCLC 473540298.
• Kuhl, H (August 2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration" (PDF). Climacteric. 8 (Suppl 1): 3–63. doi:10.1080/13697130500148875. eISSN 1473-0804. ISSN 1369-7137. PMID 16112947. S2CID 24616324.
• Wiegratz, Inka; Kuhl, Herbert (January 2006). "Metabolic and clinical effects of progestogens". The European Journal of Contraception & Reproductive Health Care. 11 (3): 153–161. doi:10.1080/13625180600772741. eISSN 1473-0782. ISSN 1362-5187. PMID 17056444. S2CID 27088428.
• Kuhl H (2011). "Pharmacology of Progestogens". J Reproduktionsmed Endokrinol. 8 (1): 157–177.
• Kuhl, H.; Schneider, H. P. G. (20 February 2013). "Progesterone – promoter or inhibitor of breast cancer". Climacteric. 16 (Suppl 1): 54–68. doi:10.3109/13697137.2013.768806. eISSN 1473-0804. ISSN 1369-7137. PMID 23336704. S2CID 20808536.
• Kuhl, H.; Wiegratz, I. (1 February 2021). "Pharmakokinetik und Pharmakodynamik der in der assistierten Reproduktion verwendeten Gestagene" [Pharmacokinetics and pharmacodynamics of progestogens used in assisted reproduction]. Gynäkologische Endokrinologie (in German). 19 (2): 105–117. doi:10.1007/s10304-020-00372-5. eISSN 1610-2908. ISSN 1610-2894. S2CID 231744549.

Studies

• Wiegratz, I.; Jung-Hoffmann, C.; Kuhl, H. (June 1995). "Effect of two oral contraceptives containing ethinylestradiol and gestodene or norgestimate upon androgen parameters and serum binding proteins". Contraception. 51 (6): 341–346. doi:10.1016/0010-7824(95)00098-U. ISSN 0010-7824. PMID 7554973.
• Herkert, Olaf; Kuhl, Herbert; Sandow, Jurgen; Busse, Rudi; Schini-Kerth, Valérie B. (4 December 2001). "Sex Steroids Used in Hormonal Treatment Increase Vascular Procoagulant Activity by Inducing Thrombin Receptor (PAR-1) Expression". Circulation. 104 (23): 2826–2831. doi:10.1161/hc4801.099737. eISSN 1524-4539. ISSN 0009-7322. PMID 11733402.
• Wiegratz, I; Lee, J.H; Kutschera, E; Winkler, U.H; Kuhl, H (August 2004). "Effect of four oral contraceptives on hemostatic parameters". Contraception. 70 (2): 97–106. doi:10.1016/j.contraception.2004.03.004. ISSN 0010-7824. PMID 15288212.

Theses/dissertations

• Kuhl, Herbert (1972). Darstellung von Steroidverbindungen mit hormoneller Langzeitwirkung [Presentation of steroid compounds with long-lasting hormonal effects] (Thesis) (in German). Frankfurt/Main: Universität Frankfurt am Main. OCLC 715315797.
• Kuhl, Herbert (1977). Die Rolle eines LH-RH-abbauenden Enzyms im Hypothalamus und in der Hypophyse der Ratte bei der Regulation der Gonadotropin-Freisetzung [The role of an LH-RH degrading enzyme in the rat hypothalamus and pituitary gland in the regulation of gonadotropin release] (Thesis) (in German). Frankfurt (Main), Univ., Habil.-Schr. OCLC 720820331.

References

1. Kuhl H (1999). "Östrogene für den Mann?" [Estrogens for the Man?]. Journal für Menopause [Ausgabe für Österreich]. 6 (2): 15–23. ISSN 1025-6873.
2. Taubert, H.-D.; Heil, H.; Kuhl, H. (1970). "Untersuchungen über die Wirkung von Äthynil-Oestradiol auf die L-Cystin-Aminopeptidosen-Aktivität im Hypothalamus der weiblichen Ratte" [Investigations on the Effect of Ethynil-Oestradiol on L-Cystine-amino-peptidase Activity in the Hypothalamus of Female Rats]. In Kracht, Joachim (ed.). Endokrinologie der Entwicklung und Reifung: 16. Symposion, Ulm, 26.-28. Februar 1970. Symposion der Deutschen Gesellschaft für Endokrinologie. Vol. 16. Berlin/Heidelberg/New York: Springer-Verlag. pp. 288–289. doi:10.1007/978-3-642-80591-2. ISBN 978-3-642-80591-2. OCLC 863921711.
3. Kuhl, H (August 2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration" (PDF). Climacteric. 8 (Suppl 1): 3–63. doi:10.1080/13697130500148875. eISSN 1473-0804. ISSN 1369-7137. PMID 16112947. S2CID 24616324.
4. "Web of Science". Clarivate. Retrieved 19 August 2022.
5. Kuhl H (2003). "Die unterschätzte Bedeutung der Gestagene bei der Hormonsubstitution" [The Underestimated Importance of Progestins in Hormone Replacement Therapy]. Journal für Menopause [Ausgabe für Österreich]. 10 (3): 6–12. ISSN 1025-6873.
6. Wiegratz I, Kuhl H (August 2004). "Progestogen therapies: differences in clinical effects?". Trends Endocrinol Metab. 15 (6): 277–85. doi:10.1016/j.tem.2004.06.006. PMID 15358281. S2CID 35891204.
7. Mueck, A. O.; Kuhl, H.; Braendle, W. (September 2004). "Ergebnisse und Kommentare zu der WHI-Studie mit Estrogen-Monotherapie" [Results of and Comments on the WHI Study with Estrogen Monotherapy]. Geburtshilfe und Frauenheilkunde (in German). 64 (9): 917–922. doi:10.1055/s-2004-821217. eISSN 1438-8804. ISSN 0016-5751. S2CID 71579060.
8. Kuhl H (September 2004). "Is the elevated breast cancer risk observed in the WHI study an artifact?". Climacteric. 7 (3): 319–22. doi:10.1080/13697130400003337. PMID 15669557.
9. Kuhl H (May 2005). "Breast cancer risk in the WHI study: the problem of obesity". Maturitas. 51 (1): 83–97. doi:10.1016/j.maturitas.2005.02.018. PMID 15883113.
10. Kuhl H, Stevenson J (June 2006). "The effect of medroxyprogesterone acetate on estrogen-dependent risks and benefits--an attempt to interpret the Women's Health Initiative results". Gynecol Endocrinol. 22 (6): 303–17. doi:10.1080/09513590600717368. PMID 16785155. S2CID 25260381.
11. Kuhl, H.; Schneider, H. P. G. (20 February 2013). "Progesterone – promoter or inhibitor of breast cancer". Climacteric. 16 (Suppl 1): 54–68. doi:10.3109/13697137.2013.768806. eISSN 1473-0804. ISSN 1369-7137. PMID 23336704. S2CID 20808536.
12. Kuhl, Herbert; Wiegratz, Inka (10 April 2017). "Das Post-Finasterid-Syndrom" [Post-finasteride syndrome]. Gynäkologische Endokrinologie (in German). 15 (2): 153–163. doi:10.1007/s10304-017-0126-2. eISSN 1610-2908. ISSN 1610-2894. S2CID 207071180.
13. Kuhl, H.; Wiegratz, I. (1 February 2021). "Pharmakokinetik und Pharmakodynamik der in der assistierten Reproduktion verwendeten Gestagene" [Pharmacokinetics and pharmacodynamics of progestogens used in assisted reproduction]. Gynäkologische Endokrinologie (in German). 19 (2): 105–117. doi:10.1007/s10304-020-00372-5. eISSN 1610-2908. ISSN 1610-2894. S2CID 231744549.