HS3ST2

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.^[5][6]

HS3ST2
Identifiers
Aliases	HS3ST2, 30ST2, 3OST2, heparan sulfate-glucosamine 3-sulfotransferase 2
External IDs	OMIM: 604056; MGI: 1333802; HomoloGene: 21220; GeneCards: HS3ST2; OMA:HS3ST2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.2 Start 22,814,162 bp[1] End 22,916,338 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F2|7 65.07 cM Start 120,991,082 bp[2] End 121,100,993 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 46 orbitofrontal cortex Region I of hippocampus proper postcentral gyrus superior frontal gyrus dorsolateral prefrontal cortex cingulate gyrus anterior cingulate cortex endothelial cell Brodmann area 9 Top expressed in lumbar spinal ganglion prefrontal cortex primary motor cortex lateral septal nucleus superior frontal gyrus visual cortex molecular layer of cerebellar cortex primary visual cortex pineal gland granular layer More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity [heparan sulfate-glucosamine 3-sulfotransferase 2 activity] [heparan sulfate-glucosamine 3-sulfotransferase 1 activity] heparan sulfate sulfotransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process circadian rhythm glycosaminoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9956 195646 Ensembl ENSG00000122254 ENSMUSG00000046321 UniProt Q9Y278 Q673U1 RefSeq (mRNA) NM_006043 NM_001081327 NM_177575 RefSeq (protein) NP_006034 NP_001074796 Location (UCSC) Chr 16: 22.81 – 22.92 Mb Chr 7: 120.99 – 121.1 Mb PubMed search [3] [4]
Wikidata
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Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system.^[6]

Role in breast cancer The HS3ST2 promoter is hypermethylated in breast cancer tissue compared to normal breast ducts, suggesting a potential involvement in the pathogenesis of the disease.^[7] Functional analysis revealed that upregulation of HS3ST2 in human breast cancer cells resulted in altered invasiveness, which was due to changes in Mitogen-activated protein kinase signaling and matrix metalloproteinase expression.^[8]