HOXD8

Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.^[5][6][7]

HOXD8
Identifiers
Aliases	HOXD8, HOX4, HOX4E, HOX5.4, homeobox D8
External IDs	OMIM: 142985; MGI: 96209; HomoloGene: 10473; GeneCards: HOXD8; OMA:HOXD8 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 176,129,694 bp[1] End 176,132,695 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C3|2 44.13 cM Start 74,534,959 bp[2] End 74,538,277 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium Achilles tendon corpus epididymis renal medulla deltoid muscle secondary oocyte human kidney body of uterus muscle of thigh left ovary Top expressed in tail of embryo medullary collecting duct right kidney triceps brachii muscle seminal vesicula gastrocnemius muscle human kidney Gonadal ridge medial head of gastrocnemius muscle efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process anterior/posterior pattern specification multicellular organism development anterior/posterior axis specification, embryo regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II skeletal system morphogenesis transcription, DNA-templated transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3234 15437 Ensembl ENSG00000175879 ENSMUSG00000027102 UniProt P13378 P23463 RefSeq (mRNA) NM_019558 NM_001199746 NM_001199747 NM_001290730 NM_001290731 NM_008276 RefSeq (protein) NP_001186675 NP_001186676 NP_062458 NP_001277659 NP_001277660 NP_032302 Location (UCSC) Chr 2: 176.13 – 176.13 Mb Chr 2: 74.53 – 74.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.^[7]