HOXC10

Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.^[5][6]

HOXC10
Identifiers
Aliases	HOXC10, HOX3I, homeobox C10
External IDs	OMIM: 605560; MGI: 96192; HomoloGene: 9680; GeneCards: HOXC10; OMA:HOXC10 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,985,065 bp[1] End 53,990,279 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 58.03 cM Start 102,875,231 bp[2] End 102,880,328 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle buccal mucosa cell renal medulla popliteal artery tibial arteries tibialis anterior muscle human kidney quadriceps femoris muscle vastus lateralis muscle Achilles tendon Top expressed in tail of embryo knee joint muscle of thigh medial head of gastrocnemius muscle lumbar subsegment of spinal cord quadriceps femoris muscle tibialis anterior muscle vastus lateralis muscle genital tubercle skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cyclin-dependent protein kinase activating kinase holoenzyme complex nucleus nuclear body nucleoplasm Biological process multicellular organism development skeletal system development proximal/distal pattern formation neuromuscular process regulation of transcription, DNA-templated embryonic limb morphogenesis transcription, DNA-templated positive regulation of cell population proliferation anterior/posterior pattern specification spinal cord motor neuron cell fate specification transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3226 209448 Ensembl ENSG00000180818 ENSMUSG00000022484 UniProt Q9NYD6 P31257 RefSeq (mRNA) NM_017409 NM_010462 RefSeq (protein) NP_059105 NP_034592 Location (UCSC) Chr 12: 53.99 – 53.99 Mb Chr 15: 102.88 – 102.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.^[6]

Pathology

• HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4.^[7]
• Methylation of the estrogen-repressed gene HOXC10 in breast cancer determines resistance to aromatase inhibitors. This epigenetic reprogramming of HOXC10 is observed in endocrine-resistant breast cancer.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000180818 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022484 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
6. "Entrez Gene: HOXC10 homeobox C10".
7. Ansari KI, Hussain I, Kasiri S, Mandal SS (Feb 2012). "HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4". Journal of Molecular Endocrinology. 48 (1): 61–75. doi:10.1530/JME-11-0078. PMID 22143955.
8. Pathiraja TN, Nayak SR, Xi Y, Jiang S, Garee JP, Edwards DP, Lee AV, Chen J, Shea MJ, Santen RJ, Gannon F, Kangaspeska S, Jelinek J, Issa JP, Richer JK, Elias A, McIlroy M, Young LS, Davidson NE, Schiff R, Li W, Oesterreich S (Mar 2014). "Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer". Science Translational Medicine. 6 (229): 229ra41. doi:10.1126/scitranslmed.3008326. PMC 4277862. PMID 24670685.

Further reading

• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (Dec 1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America. 83 (23): 9104–8. Bibcode:1986PNAS...83.9104R. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
• Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B (Oct 1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Letters. 415 (3): 263–7. Bibcode:1997FEBSL.415..263F. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979. S2CID 26075369.
• de Stanchina E, Gabellini D, Norio P, Giacca M, Peverali FA, Riva S, Falaschi A, Biamonti G (Jun 2000). "Selection of homeotic proteins for binding to a human DNA replication origin". Journal of Molecular Biology. 299 (3): 667–80. doi:10.1006/jmbi.2000.3782. PMID 10835276.
• Sandrock B, Egly JM (Sep 2001). "A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH". The Journal of Biological Chemistry. 276 (38): 35328–33. doi:10.1074/jbc.M105570200. PMID 11445587.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Gabellini D, Colaluca IN, Vodermaier HC, Biamonti G, Giacca M, Falaschi A, Riva S, Peverali FA (Jul 2003). "Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression". The EMBO Journal. 22 (14): 3715–24. doi:10.1093/emboj/cdg340. PMC 165610. PMID 12853486.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Zhai Y, Kuick R, Nan B, Ota I, Weiss SJ, Trimble CL, Fearon ER, Cho KR (Nov 2007). "Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion". Cancer Research. 67 (21): 10163–72. doi:10.1158/0008-5472.CAN-07-2056. PMID 17974957.

External links

• HOXC10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.