HOXB13

Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13 gene.^[4][5][6]

HOXB13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRA
Identifiers
Aliases	HOXB13, PSGD, homeobox B13, HPC9
External IDs	OMIM: 604607; MGI: 107730; HomoloGene: 4640; GeneCards: HOXB13; OMA:HOXB13 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,724,763 bp[1] End 48,728,750 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum mucosa of sigmoid colon prostate mucosa of transverse colon gonad vagina epithelium of colon muscle layer of sigmoid colon urinary bladder muscle tissue n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific methyl-CpG binding Cellular component nucleus transcription regulator complex nucleoplasm Biological process response to testosterone morphogenesis of an epithelium multicellular organism development regulation of growth regulation of transcription, DNA-templated response to wounding prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis angiogenesis transcription, DNA-templated epithelial cell maturation involved in prostate gland development epidermis development prostate gland development negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10481 15408 Ensembl ENSG00000159184 ENSMUSG00000049604 UniProt Q92826 P70321 RefSeq (mRNA) NM_006361 NM_008267 RefSeq (protein) NP_006352 NP_032293 Location (UCSC) Chr 17: 48.72 – 48.73 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster on chromosome 17 in the 17q21.32 region.^[6] Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.^[7][8]

See also

• Homeobox

References

1. GRCh38: Ensembl release 89: ENSG00000159184 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Zeltser L, Desplan C, Heintz N (Aug 1996). "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity". Development. 122 (8): 2475–84. doi:10.1242/dev.122.8.2475. PMID 8756292.
5. Stelnicki EJ, Arbeit J, Cass DL, Saner C, Harrison M, Largman C (Jul 1998). "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds". The Journal of Investigative Dermatology. 111 (1): 57–63. doi:10.1046/j.1523-1747.1998.00238.x. PMID 9665387.
6. "Entrez Gene: HOXB13 homeobox B13".
7. Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y, Bizon C, Yan G, Gielzak M, Partin AW, Shanmugam V, Izatt T, Sinari S, Craig DW, Zheng SL, Walsh PC, Montie JE, Xu J, Carpten JD, Isaacs WB, Cooney KA (Jan 2012). "Germline mutations in HOXB13 and prostate-cancer risk". The New England Journal of Medicine. 366 (2): 141–9. doi:10.1056/NEJMoa1110000. PMC 3779870. PMID 22236224.
8. Dupont WD, Breyer J, Johnson SH, Plummer WD, Smith JR (May 2021). "Prostate cancer risk variants of the HOXB genetic locus". Scientific Reports. 11 (1): 11385. Bibcode:2021NatSR..1111385D. doi:10.1038/s41598-021-89399-7. PMC 8167119. PMID 34059701. S2CID 235269663.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–58. doi:10.1128/MCB.17.11.6448. PMC 232497. PMID 9343407.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Kömüves LG, Ma XK, Stelnicki E, Rozenfeld S, Oda Y, Largman C (Jun 2003). "HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development". Developmental Dynamics. 227 (2): 192–202. doi:10.1002/dvdy.10290. PMID 12761847. S2CID 42243036.
• Jung C, Kim RS, Lee SJ, Wang C, Jeng MH (May 2004). "HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4". Cancer Research. 64 (9): 3046–51. doi:10.1158/0008-5472.CAN-03-2614. PMID 15126340.
• Jung C, Kim RS, Zhang HJ, Lee SJ, Jeng MH (Dec 2004). "HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling". Cancer Research. 64 (24): 9185–92. doi:10.1158/0008-5472.CAN-04-1330. PMID 15604291.
• Zhao Y, Yamashita T, Ishikawa M (Apr 2005). "Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer". Oncology Reports. 13 (4): 721–6. doi:10.3892/or.13.4.721. PMID 15756448.
• Jung C, Kim RS, Zhang H, Lee SJ, Sheng H, Loehrer PJ, Gardner TA, Jeng MH, Kao C (Jun 2005). "HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation". British Journal of Cancer. 92 (12): 2233–9. doi:10.1038/sj.bjc.6602631. PMC 2361828. PMID 15928669.
• Symmans WF (Apr 2006). "Genomic testing for sensitivity of breast cancer to hormonal therapy". Clinical Cancer Research. 12 (7 Pt 1): 1954–5. doi:10.1158/1078-0432.CCR-06-0289. PMID 16609001.
• Goetz MP, Suman VJ, Ingle JN, Nibbe AM, Visscher DW, Reynolds CA, Lingle WL, Erlander M, Ma XJ, Sgroi DC, Perez EA, Couch FJ (Apr 2006). "A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen". Clinical Cancer Research. 12 (7 Pt 1): 2080–7. doi:10.1158/1078-0432.CCR-05-1263. PMID 16609019. S2CID 9930864.
• Cazal C, Sobral AP, de Almeida FC, das Graças Silva-Valenzuela M, Durazzo MD, Nunes FD (Jul 2006). "The homeobox HOXB13 is expressed in human minor salivary gland". Oral Diseases. 12 (4): 424–7. doi:10.1111/j.1601-0825.2005.01218.x. PMID 16792730.
• Ma XJ, Hilsenbeck SG, Wang W, Ding L, Sgroi DC, Bender RA, Osborne CK, Allred DC, Erlander MG (Oct 2006). "The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer". Journal of Clinical Oncology. 24 (28): 4611–9. doi:10.1200/JCO.2006.06.6944. PMID 17008703.
• Muthusamy V, Duraisamy S, Bradbury CM, Hobbs C, Curley DP, Nelson B, Bosenberg M (Dec 2006). "Epigenetic silencing of novel tumor suppressors in malignant melanoma". Cancer Research. 66 (23): 11187–93. doi:10.1158/0008-5472.CAN-06-1274. PMID 17145863.
• Miao J, Wang Z, Provencher H, Muir B, Dahiya S, Carney E, Leong CO, Sgroi DC, Orsulic S (Oct 2007). "HOXB13 promotes ovarian cancer progression". Proceedings of the National Academy of Sciences of the United States of America. 104 (43): 17093–8. Bibcode:2007PNAS..10417093M. doi:10.1073/pnas.0707938104. PMC 2040435. PMID 17942676.
• Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y, Bizon C, Yan G, Gielzak M, Partin AW, Shanmugam V, Izatt T, Sinari S, Craig DW, Zheng SL, Walsh PC, Montie JE, Xu J, Carpten JD, Isaacs WB, Cooney KA (Jan 2012). "Germline mutations in HOXB13 and prostate-cancer risk". The New England Journal of Medicine. 366 (2): 141–9. doi:10.1056/NEJMoa1110000. PMC 3779870. PMID 22236224.

External links

• HOXB13+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q92826 (Homeobox protein Hox-B13) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.