HOXA4

Homeobox A4, also known as HOXA4, is a protein which in humans is encoded by the HOXA4 gene.^[5][6]

HOXA4
Identifiers
Aliases	HOXA4, HOX1, HOX1D, homeobox A4
External IDs	OMIM: 142953; MGI: 96176; HomoloGene: 37583; GeneCards: HOXA4; OMA:HOXA4 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.2 Start 27,128,507 bp[1] End 27,130,780 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 25.4 cM Start 52,166,651 bp[2] End 52,168,733 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa C1 segment muscle of thigh fallopian tube Descending thoracic aorta left uterine tube right uterine tube gastrocnemius muscle right lung mucosa of esophagus Top expressed in seminiferous tubule hair bulb spermatocyte CA3 field spermatid inner root sheath tail of embryo brown adipose tissue thyroid gland outer root sheath of hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus nuclear body Biological process multicellular organism development anatomical structure morphogenesis regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II skeletal system development anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II embryonic skeletal system morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3201 15401 Ensembl ENSG00000197576 ENSMUSG00000000942 UniProt Q00056 P06798 RefSeq (mRNA) NM_002141 NM_008265 RefSeq (protein) NP_002132 NP_032291 Location (UCSC) Chr 7: 27.13 – 27.13 Mb Chr 6: 52.17 – 52.17 Mb PubMed search [3] [4]
Wikidata
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Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes.^[7] Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.^[5]

See also

• Homeobox