HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.[1]
 | ||
| HLA-B (alpha)-β2MG with bound peptide | ||
major histocompatibility complex (human), class I, B38 | ||
| Alleles | B*3801, 3802, . . | |
| Structure (See HLA-B) | ||
| Shared data | ||
| Locus | chr.6 6p21.31 | |
B38 is a split antigen of the broad antigen B16, and is a sister type of B39. The B*3801 allele is more common in Eastern, Southern and Southeastern Europe, while the B*3802 allele is more common in the Far East.
Serotype
| B*38 | B38 | B16 | B39 | Sample | |
| allele | % | % | % | size (N) | |
| *3801 | 94 | 1 | 1 | 2317 | |
| *3802 | 87 | 2 | 2 | 788 | |
| Alleles link-out to IMGT/HLA Databease at EBI | |||||
Alleles
| freq | ||
| ref. | Population | (%) |
| [3] | Israel Ashk. and Non Ashk. Jews | 6.9 |
| Croatia | 6.7 | |
| Italy North | 6.7 | |
| Azores Central Islands | 5.4 | |
| Sudanese | 5.3 | |
| Czech Republic | 4.7 | |
| Georgia Tbilisi Georgians | 4.6 | |
| Macedonia (4) | 4.6 | |
| Spain Eastern Andalusia | 4.1 | |
| Georgia Svaneti Svans | 3.8 | |
| New Mexico Canoncito Navajo | 3.7 | |
| Bulgaria | 3.6 | |
| Brazil Belo Horizonte | 3.2 | |
| Romanian | 3.2 | |
| Tunisia | 3.0 | |
| Thailand | 2.8 | |
| Israel Arab Druse | 2.5 | |
| USA Caucasian (2) | 2.5 | |
| Tunisia Tunis | 2.3 | |
| Brazil | 2.2 | |
| Indig. Australian Cape York Penin. | 2.0 | |
| France South East | 1.9 | |
| Georgia Tbilisi Kurds | 1.7 | |
| Australia New South Wales | 1.5 | |
| China Guangzhou | 1.5 | |
| Mexico Guadalajara Mestizos (2) | 1.5 | |
| China Yunnan Lisu | 1.4 | |
| Jordan Amman | 1.4 | |
| Morocco Nador Metalsa Class I | 1.4 | |
| China South Han | 1.2 | |
| Mexico Mestizos | 1.2 | |
| Saudi Arabia Guraiat and Hail | 1.2 | |
| Finland | 1.1 | |
| USA North American Natives | 1.1 | |
| American Samoa | 1.0 | |
| China North Han | 1.0 | |
| India North Hindus | 1.0 | |
| Mexico Mixtec Oaxaca | 1.0 | |
| Hong Kong Chinese | 0.9 | |
| Ireland Northern | 0.9 | |
| Cape Verde Southeastern Islands | 0.8 | |
| China Beijing | 0.8 | |
| Ireland South | 0.8 |
Disease
A higher frequency of HLA-B38 was noted psoriatic arthritis patients with erythroderma.[4] Psoriatic arthritis is linked to MICA and/or B39 in other peoples.[5] In Pemphigus vulgaris a haplotype containing B38 was identified and found to be shared between Spanish and Jewish patients.[6] Linkage studies indicate a factor in the HLA-class I region is more greatly associated, with HLA-B38 so far the only linked allele[7]
| freq | ||
| ref. | Population | (%) |
| [3] | Taiwan Tao | 11.0 |
| China Guangxi Maonan | 8.3 | |
| China South Han | 7.1 | |
| Singapore Javan. Indonesians | 7.1 | |
| Singapore Chinese Han | 6.4 | |
| Taiwan Minnan pop 1 | 6.4 | |
| China Guangzhou | 6.0 | |
| Philippines Ivatan | 6.0 | |
| Hong Kong Chinese | 5.4 | |
| Singapore Chinese | 4.7 | |
| Singapore Riau Malay | 4.5 | |
| China Guangzhou Han | 4.3 | |
| India West Bhils | 4.0 | |
| Taiwan Hakka | 3.6 | |
| Singapore Thai | 3.5 | |
| Taiwan Siraya | 2.9 | |
| Taiwan Pazeh | 1.8 | |
| India Mumbai Marathas | 1.2 | |
| South Korea pop 3 | 1.1 | |
| Taiwan Puyuma | 1.0 | |
| Taiwan Saisiat | 1.0 | |
| China Beijing | 0.8 | |
| Brazil | 0.7 |
References
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