Human leukocyte antigen serotype From Wikipedia, the free encyclopedia
HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.[1]
HLA-B (alpha)-β2MG with bound peptide | ||
major histocompatibility complex (human), class I, B38 | ||
Alleles | B*3801, 3802, . . | |
Structure (See HLA-B) | ||
Shared data | ||
Locus | chr.6 6p21.31 |
B38 is a split antigen of the broad antigen B16, and is a sister type of B39. The B*3801 allele is more common in Eastern, Southern and Southeastern Europe, while the B*3802 allele is more common in the Far East.
B*38 | B38 | B16 | B39 | Sample | |
allele | % | % | % | size (N) | |
*3801 | 94 | 1 | 1 | 2317 | |
*3802 | 87 | 2 | 2 | 788 | |
Alleles link-out to IMGT/HLA Databease at EBI |
freq | ||
ref. | Population | (%) |
[3] | Israel Ashk. and Non Ashk. Jews | 6.9 |
Croatia | 6.7 | |
Italy North | 6.7 | |
Azores Central Islands | 5.4 | |
Sudanese | 5.3 | |
Czech Republic | 4.7 | |
Georgia Tbilisi Georgians | 4.6 | |
Macedonia (4) | 4.6 | |
Spain Eastern Andalusia | 4.1 | |
Georgia Svaneti Svans | 3.8 | |
New Mexico Canoncito Navajo | 3.7 | |
Bulgaria | 3.6 | |
Brazil Belo Horizonte | 3.2 | |
Romanian | 3.2 | |
Tunisia | 3.0 | |
Thailand | 2.8 | |
Israel Arab Druse | 2.5 | |
USA Caucasian (2) | 2.5 | |
Tunisia Tunis | 2.3 | |
Brazil | 2.2 | |
Indig. Australian Cape York Penin. | 2.0 | |
France South East | 1.9 | |
Georgia Tbilisi Kurds | 1.7 | |
Australia New South Wales | 1.5 | |
China Guangzhou | 1.5 | |
Mexico Guadalajara Mestizos (2) | 1.5 | |
China Yunnan Lisu | 1.4 | |
Jordan Amman | 1.4 | |
Morocco Nador Metalsa Class I | 1.4 | |
China South Han | 1.2 | |
Mexico Mestizos | 1.2 | |
Saudi Arabia Guraiat and Hail | 1.2 | |
Finland | 1.1 | |
USA North American Natives | 1.1 | |
American Samoa | 1.0 | |
China North Han | 1.0 | |
India North Hindus | 1.0 | |
Mexico Mixtec Oaxaca | 1.0 | |
Hong Kong Chinese | 0.9 | |
Ireland Northern | 0.9 | |
Cape Verde Southeastern Islands | 0.8 | |
China Beijing | 0.8 | |
Ireland South | 0.8 |
A higher frequency of HLA-B38 was noted psoriatic arthritis patients with erythroderma.[4] Psoriatic arthritis is linked to MICA and/or B39 in other peoples.[5] In Pemphigus vulgaris a haplotype containing B38 was identified and found to be shared between Spanish and Jewish patients.[6] Linkage studies indicate a factor in the HLA-class I region is more greatly associated, with HLA-B38 so far the only linked allele[7]
freq | ||
ref. | Population | (%) |
[3] | Taiwan Tao | 11.0 |
China Guangxi Maonan | 8.3 | |
China South Han | 7.1 | |
Singapore Javan. Indonesians | 7.1 | |
Singapore Chinese Han | 6.4 | |
Taiwan Minnan pop 1 | 6.4 | |
China Guangzhou | 6.0 | |
Philippines Ivatan | 6.0 | |
Hong Kong Chinese | 5.4 | |
Singapore Chinese | 4.7 | |
Singapore Riau Malay | 4.5 | |
China Guangzhou Han | 4.3 | |
India West Bhils | 4.0 | |
Taiwan Hakka | 3.6 | |
Singapore Thai | 3.5 | |
Taiwan Siraya | 2.9 | |
Taiwan Pazeh | 1.8 | |
India Mumbai Marathas | 1.2 | |
South Korea pop 3 | 1.1 | |
Taiwan Puyuma | 1.0 | |
Taiwan Saisiat | 1.0 | |
China Beijing | 0.8 | |
Brazil | 0.7 |
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