HIPK1

Homeodomain-interacting protein kinase 1 is an enzyme that, in humans is encoded by the HIPK1 gene.^[5]

HIPK1
Identifiers
Aliases	HIPK1, Myak, Nbak2, homeodomain interacting protein kinase 1
External IDs	OMIM: 608003; MGI: 1314873; HomoloGene: 56483; GeneCards: HIPK1; OMA:HIPK1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 113,929,324 bp[1] End 113,977,869 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 103,647,131 bp[2] End 103,698,879 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell cerebellar vermis mucosa of paranasal sinus paraflocculus of cerebellum Epithelium of choroid plexus caput epididymis buccal mucosa cell thymus bone marrow trabecular bone Top expressed in vestibular membrane of cochlear duct blood tibiofemoral joint fetal liver hematopoietic progenitor cell granulocyte genital tubercle gastrula stroma of bone marrow right lung submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytoplasm PML body nuclear speck nucleus nucleoplasm centrosome cytosol Biological process eye development intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of transcription, DNA-templated retina layer formation extrinsic apoptotic signaling pathway adherens junction assembly phosphorylation iris morphogenesis regulation of tumor necrosis factor-mediated signaling pathway transcription, DNA-templated positive regulation of angiogenesis protein phosphorylation embryonic camera-type eye morphogenesis lens induction in camera-type eye neuron differentiation positive regulation of cell population proliferation embryonic retina morphogenesis in camera-type eye definitive hemopoiesis smoothened signaling pathway endothelial cell apoptotic process anterior/posterior pattern specification regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 204851 15257 Ensembl ENSG00000163349 ENSMUSG00000008730 UniProt Q86Z02 O88904 RefSeq (mRNA) NM_152696 NM_181358 NM_198268 NM_198269 NM_001369806 NM_001369807 NM_001301304 NM_001301306 NM_010432 RefSeq (protein) NP_689909 NP_852003 NP_938009 NP_938010 NP_001356735 NP_001356736 NP_001288233 NP_001288235 NP_034562 Location (UCSC) Chr 1: 113.93 – 113.98 Mb Chr 3: 103.65 – 103.7 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.^[5]

Interactions

HIPK1 has been shown to interact with P53.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000163349 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008730 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: HIPK1 homeodomain interacting protein kinase 1".
6. Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK (Apr 2003). "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)". Proceedings of the National Academy of Sciences of the United States of America. 100 (9): 5431–6. Bibcode:2003PNAS..100.5431K. doi:10.1073/pnas.0530308100. PMC 154362. PMID 12702766.

Further reading

• Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y (Oct 1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors". The Journal of Biological Chemistry. 273 (40): 25875–9. doi:10.1074/jbc.273.40.25875. PMID 9748262.
• Ecsedy JA, Michaelson JS, Leder P (Feb 2003). "Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity". Molecular and Cellular Biology. 23 (3): 950–60. doi:10.1128/MCB.23.3.950-960.2003. PMC 140690. PMID 12529400.
• Kondo S, Lu Y, Debbas M, Lin AW, Sarosi I, Itie A, Wakeham A, Tuan J, Saris C, Elliott G, Ma W, Benchimol S, Lowe SW, Mak TW, Thukral SK (Apr 2003). "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)". Proceedings of the National Academy of Sciences of the United States of America. 100 (9): 5431–6. Bibcode:2003PNAS..100.5431K. doi:10.1073/pnas.0530308100. PMC 154362. PMID 12702766.
• Song JJ, Lee YJ (Nov 2003). "Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization". The Journal of Biological Chemistry. 278 (47): 47245–52. doi:10.1074/jbc.M213201200. PMID 12968034.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Li X, Zhang R, Luo D, Park SJ, Wang Q, Kim Y, Min W (Apr 2005). "Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation". The Journal of Biological Chemistry. 280 (15): 15061–70. doi:10.1074/jbc.M414262200. PMID 15701637.