HHIP

Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene.^[5][6][7]

HHIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WFT, 2WFX, 2WG3, 2WG4, 3HO3, 3HO4, 3HO5
Identifiers
Aliases	HHIP, HIP, hedgehog interacting protein
External IDs	OMIM: 606178; MGI: 1341847; HomoloGene: 32469; GeneCards: HHIP; OMA:HHIP - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.21 Start 144,646,156 bp[1] End 144,745,271 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C2|8 37.95 cM Start 80,692,480 bp[2] End 80,784,635 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum endothelial cell globus pallidus inferior ganglion of vagus nerve internal globus pallidus external globus pallidus tibia subthalamic nucleus synovial joint epithelium of colon Top expressed in left lung lobe membranous bone habenula Dermatocranium maxilla mandible lumbar subsegment of spinal cord molar iris rib More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding protein binding catalytic activity hedgehog family protein binding Cellular component cytoplasm membrane plasma membrane integral component of plasma membrane extracellular region cell surface ciliary membrane nucleus Biological process negative regulation of smoothened signaling pathway regulation of fibroblast growth factor receptor signaling pathway skeletal system morphogenesis animal organ morphogenesis neuroblast proliferation smoothened signaling pathway negative regulation of signal transduction dorsal/ventral pattern formation epithelial tube branching involved in lung morphogenesis signal transduction negative regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64399 15245 Ensembl ENSG00000164161 ENSMUSG00000064325 UniProt Q96QV1 Q7TN16 RefSeq (mRNA) NM_022475 NM_020259 RefSeq (protein) NP_071920 NP_064655 Location (UCSC) Chr 4: 144.65 – 144.75 Mb Chr 8: 80.69 – 80.78 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein similar to the mouse hedgehog interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.^[7]