HHIP

Hedgehog interacting protein (HHIP) is a protein that in humans is encoded by the HHIP gene.^[5][6][7]

HHIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WFT, 2WFX, 2WG3, 2WG4, 3HO3, 3HO4, 3HO5
Identifiers
Aliases	HHIP, HIP, hedgehog interacting protein
External IDs	OMIM: 606178; MGI: 1341847; HomoloGene: 32469; GeneCards: HHIP; OMA:HHIP - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.21 Start 144,646,156 bp[1] End 144,745,271 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C2|8 37.95 cM Start 80,692,480 bp[2] End 80,784,635 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum endothelial cell globus pallidus inferior ganglion of vagus nerve internal globus pallidus external globus pallidus tibia subthalamic nucleus synovial joint epithelium of colon Top expressed in left lung lobe membranous bone habenula Dermatocranium maxilla mandible lumbar subsegment of spinal cord molar iris rib More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding metal ion binding protein binding catalytic activity hedgehog family protein binding Cellular component cytoplasm membrane plasma membrane integral component of plasma membrane extracellular region cell surface ciliary membrane nucleus Biological process negative regulation of smoothened signaling pathway regulation of fibroblast growth factor receptor signaling pathway skeletal system morphogenesis animal organ morphogenesis neuroblast proliferation smoothened signaling pathway negative regulation of signal transduction dorsal/ventral pattern formation epithelial tube branching involved in lung morphogenesis signal transduction negative regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64399 15245 Ensembl ENSG00000164161 ENSMUSG00000064325 UniProt Q96QV1 Q7TN16 RefSeq (mRNA) NM_022475 NM_020259 RefSeq (protein) NP_071920 NP_064655 Location (UCSC) Chr 4: 144.65 – 144.75 Mb Chr 8: 80.69 – 80.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein similar to the mouse hedgehog interacting protein, a regulatory component of the Hedgehog signaling pathway. Members of the hedgehog family are evolutionarily conserved proteins which are involved in many fundamental processes in embryonic development, including anteroposterior patterns of limbs and regulation of left-right asymmetry.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000164161 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000064325 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bak M, Hansen C, Friis Henriksen K, Tommerup N (Jul 2001). "The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21→q31.3". Cytogenet Cell Genet. 92 (3–4): 300–3. doi:10.1159/000056918. PMID 11435703. S2CID 32938414.
6. Ingham PW, McMahon AP (Dec 2001). "Hedgehog signaling in animal development: paradigms and principles". Genes Dev. 15 (23): 3059–87. doi:10.1101/gad.938601. PMID 11731473.
7. "Entrez Gene: HHIP hedgehog interacting protein".

Further reading

• Chuang PT, McMahon AP (1999). "Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein". Nature. 397 (6720): 617–21. Bibcode:1999Natur.397..617C. doi:10.1038/17611. PMID 10050855. S2CID 204991314.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Olsen CL, Hsu PP, Glienke J, et al. (2004). "Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors". BMC Cancer. 4: 43. doi:10.1186/1471-2407-4-43. PMC 512291. PMID 15294024.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kayed H, Kleeff J, Esposito I, et al. (2005). "Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas". Mol. Carcinog. 42 (4): 183–92. doi:10.1002/mc.20088. PMID 15754313. S2CID 85407133.
• Martin ST, Sato N, Dhara S, et al. (2006). "Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms". Cancer Biol. Ther. 4 (7): 728–33. doi:10.4161/cbt.4.7.1802. PMID 15970691.